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Ehjcardiovascrec

[...]altered expression of PLB and SLN has been reported in many cardiac diseases. [...]SERCA2a is a major regulator of intracellular Ca2+ homeostasis, and changes in the expression and activity of ...

Cardiovascular Research, Periasamy, Muthu, Bhupathy, Poornima, Babu, Gopal J.

Date : 15/01/2008 Item size : 471288 bytes
Ehjcardiovascrec

Introduction Abnormal intracellular calcium (Ca2+) handling, and in particular, dysregulated Ca2+ release from the sarcoplasmic reticulum (SR), has been implicated in a range of cardiac diseases, ...

Cardiovascular Research, Kalyanasundaram, Anuradha, Lacombe, Véronique A., Belevych, Andriy E., Brunello, Lucia, Carnes, Cynthia A., Janssen, Paul M.L., Knollmann, Bjørn C., Periasamy, Muthu, ...

Date : 01/05/2013
Ehjcardiovascrec

Abstract Objective: Phospholamban ablation or ectopic expression of SERCA1a in the heart results in significant increases in cardiac contractile parameters. Methods: Transgenic mice with cardiac ...

Cardiovascular Research, Zhao, Wen, Frank, Konrad F, Chu, Guoxiang, Gerst, Michael J, Schmidt, Albrecht G, Ji, Yong, Periasamy, Muthu, Kranias, Evangelia G

Date : 01/01/2003
Ehjcardiovascrec

Conclusions The findings of the present study demonstrate that expression of mutant CASQ2D307H in the mouse heart results in abnormal myocyte Ca2+ handling and predisposes to complex ventricular ...

Cardiovascular Research, Dirksen, Wessel P., Lacombe, Veronique A., Chi, Mei, Kalyanasundaram, Anuradha, Viatchenko-Karpinski, Serge, Terentyev, Dmitry, Zhou, Zhixiang, Vedamoorthyrao, Srikanth, Li, ...

Date : 01/07/2007 Item size : 315930 bytes
Ehjcardiovascrec

In this study, we tested the hypothesis that SLN is a regulator of SR Ca2+ transport function by overexpressing SLN in adult rat ventricular myocytes which express low levels of SLN. In smaller ...

Cardiovascular Research, Babu, Gopal J., Zheng, Zhaolun, Natarajan, Poornima, Wheeler, Debra, Janssen, Paul M., Periasamy, Muthu

Date : 01/01/2005
Ehjcardiovascrec

Abstract Objective: Phospholamban ablation or ectopic expression of SERCA1a in the heart results in significant increases in cardiac contractile parameters. Methods: Transgenic mice with cardiac ...

Cardiovascular Research, Zhao, Wen, Frank, Konrad F, Chu, Guoxiang, Gerst, Michael J, Schmidt, Albrecht G, Ji, Yong, Periasamy, Muthu, Kranias, Evangelia G

Date : 01/01/2003
Ehjcardiovascrec

Conclusions The findings of the present study demonstrate that expression of mutant CASQ2D307H in the mouse heart results in abnormal myocyte Ca2+ handling and predisposes to complex ventricular ...

Cardiovascular Research, Dirksen, Wessel P., Lacombe, Veronique A., Chi, Mei, Kalyanasundaram, Anuradha, Viatchenko-Karpinski, Serge, Terentyev, Dmitry, Zhou, Zhixiang, Vedamoorthyrao, Srikanth, Li, ...

Date : 01/07/2007