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Dephosphorylated PLN inhibits the SR Ca2+ pump, whereas phosphorylation of PLN, at either Ser16 by PKA or Thr17 by calmodulin-dependent protein kinase II (CaMKII), reverses this inhibition, thus ...

Cardiovascular Research, Review, Alicia Mattiazzi, Cecilia Mundiña-Weilenmann, Chu Guoxiang, Leticia Vittone, Evangelia Kranias

Date : 01/12/2005 Item size : 413808 bytes

Methods and results Repeated Ca2+ sparks were induced from individual clusters of ryanodine receptors (RyRs) in quiescent rat ventricular myocytes, and we examined how changes in RyR gating ...

Cardiovascular Research, Original Article, Hena R. Ramay, Ona Z. Liu, Eric A. Sobie

Date : 01/09/2011 Item size : 285833 bytes

Here, we review the current knowledge about the molecular pathophysiology of CPVT and we discuss some potentially innovative strategies for controlling calcium-handling abnormalities in CPVT that may ...

Cardiovascular Research, Review, Nian Liu, Silvia G. Priori

Date : 15/01/2008 Item size : 341044 bytes

Methods Using simulations in a model of the guinea pig ventricular myocyte, we investigate the mutation's effect on SR Ca2+ storage, the Ca2+ transient (CaT), and its indirect effect on ionic ...

Cardiovascular Research, Original Article, Gregory M. Faber, Yoram Rudy

Date : 01/07/2007 Item size : 256495 bytes

Abstract Aims Mutations in the cardiac ryanodine receptor Ca2+ release channel, RyR2, underlie catecholaminergic polymorphic ventricular tachycardia (CPVT), an inherited life-threatening ...

Cardiovascular Research, Original Article, Simon Sedej, Frank R. Heinzel, Stefanie Walther, Nataliya Dybkova, Paulina Wakula, Jan Groborz, Phillip Gronau, Lars S. Maier, Marc A. Vos, F. Anthony Lai, ...

Date : 01/07/2010

More than a century ago, Traube noted that patients with severe congestive heart failure tend to have alternating strong and weak pulses, or pulsus alternans [8]. [...]mechanical restitution, a ...

Cardiovascular Research, Review, Ronald M Phillips, Prakash Narayan, Ana M Gómez, Keith Dilly, Larry R Jones, W.Jonathan Lederer, Ruth A Altschuld

Date : 01/02/1998

Pharmacological inhibition of CaMKII-but not of protein kinase A-mediated PLB phosphorylation totally abolished the increased effects of β-adrenergic stimulation on cardiac contractility and ...

Cardiovascular Research, Original Article in Review Focus Series on Calmodulin and Ca, Sevdalina Yurukova, Ana Kilić, Katharina Völker, Kirsten Leineweber, Nataliya Dybkova, Lars S. Maier, ...

Date : 01/03/2007

Abstract Objectives: Human cardiac muscle from failing heart shows a decrease in active tension development and a rise in diastolic tension at stimulation frequencies above 5060 beats/min due to both ...

Cardiovascular Research, Original Article, Karin R Sipido, Tania Stankovicova, Willem Flameng, Johan Vanhaecke, Fons Verdonck

Date : 01/02/1998

The possibility of replacement and/or supporting the failing heart with new cardiomyocytes from stem cells, implanted or recruited locally, is one of the exciting possibilities under investigation ...

Cardiovascular Research, Editorial, Karin R. Sipido, David Eisner

Date : 01/11/2005

Abstract The cardiac SR Ca2+-ATPase (SERCA2a) regulates intracellular Ca2+-handling and thus, plays a crucial role in initiating cardiac contraction and relaxation. In human heart failure patients, ...

Cardiovascular Research, Review, Konrad F Frank, Birgit Bölck, Erland Erdmann, Robert H.G Schwinger

Date : 01/01/2003