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Ehjcardiovascrec

Three factors combine to the enhanced propensity for the occurrence of delayed afterdepolarizations: (1) increased activity of the Na/Ca exchanger, (2) a reduced inward rectifier, (3) residual ...

Cardiovascular Research, Review, Michiel J Janse

Date : 01/02/2004 Item size : 449802 bytes
Ehjcardiovascrec

Abstract Objectives: To assess the phosphorylation of myocardial phospholamban (PLB) and quantify protein levels of PLB and sarco/endoplasmic reticulum Ca2+ ATPase type 2 (SERCA 2) in a rabbit model ...

Cardiovascular Research, Original Article, Susan Currie, Godfrey L. Smith

Date : 01/01/1999 Item size : 286941 bytes
Ehjcardiovascrec

Introduction The low resistance of the pulmonary circulation, a function of its unique structure and regulation, normally allows it to accept the entire cardiac output in the pulmonary vascular bed ...

Cardiovascular Research, Editorial, Jesus Prieto-Lloret, Philip I. Aaronson

Date : 15/07/2014 Item size : 173998 bytes
Ehjcardiovascrec

[...]altered expression of PLB and SLN has been reported in many cardiac diseases. [...]SERCA2a is a major regulator of intracellular Ca2+ homeostasis, and changes in the expression and activity of ...

Cardiovascular Research, Review, Muthu Periasamy, Poornima Bhupathy, Gopal J. Babu

Date : 15/01/2008 Item size : 520644 bytes
Ehjcardiovascrec

Abstract The progress made in our understanding of the pathophysiology and treatment of congestive heart failure (CHF) would not have been possible without a number of animal models of heart failure ...

Cardiovascular Research, Review, Gerd Hasenfuss

Date : 01/07/1998
Ehjcardiovascrec

Defective EC-coupling in heart failure may result from altered density or function of proteins relevant for calcium homeostasis. Knowledge of these alterations is a prerequisite for understanding ...

Cardiovascular Research, Review, Gerd Hasenfuss

Date : 01/02/1998
Ehjcardiovascrec

During relaxation, Ca2+ is actively transported from the cytosol into the sarcoplasmic reticulum; during contraction, this sequestered Ca2+ is passively released into the cytosol through ...

Cardiovascular Research, Review, Matthew A Movsesian, Robert H.G Schwinger

Date : 01/02/1998
Ehjcardiovascrec

Abstract Objective: Heart failure is associated with reduced function of sarcoplasmic reticulum (SR) Ca2+-ATPase (SERCA2a) but increased function of sarcolemmal Na+/Ca2+ exchanger (NCX), leading to ...

Cardiovascular Research, Original Article, Lars S. Maier, Christian Wahl-Schott, Wiebke Horn, Stefan Weichert, Christian Pagel, Stefan Wagner, Nataliya Dybkova, Oliver J. Müller, Michael ...

Date : 01/09/2005
Ehjcardiovascrec

Introduction Mitochondrial dysfunction poses severe challenges to cells that are heavily energy-dependent, such as cardiomyocytes, and it has been shown to underlie pathological conditions including ...

Cardiovascular Research, ORIGINAL ARTICLES: FOCUS ON MITOCHONDRIA IN CARDIAC DISEASE, Sandra L. Hänninen, Jarkko J. Ronkainen, Hanna Leskinen, Pasi Tavi

Date : 01/10/2010
Ehjcardiovascrec

The possibility of replacement and/or supporting the failing heart with new cardiomyocytes from stem cells, implanted or recruited locally, is one of the exciting possibilities under investigation ...

Cardiovascular Research, Editorial, Karin R. Sipido, David Eisner

Date : 01/11/2005