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Here, we review the current knowledge about the molecular pathophysiology of CPVT and we discuss some potentially innovative strategies for controlling calcium-handling abnormalities in CPVT that may ...

Cardiovascular Research, Review, Nian Liu, Silvia G. Priori

Date : 15/01/2008 Item size : 341044 bytes

Studies have revealed substantial ultrastructural alterations in several parts of the cardiomyocytes during cardiac disease, including the sarcoplasmic reticulum (SR)2 and transverse (T)-tubules,3,4 ...

Cardiovascular Research, Editorial, Fredrik Swift, Geir Christensen

Date : 01/09/2012 Item size : 179116 bytes

Abstract Background: Alterations in the cyclic AMP-dependent regulation of the cardiac ryanodine receptor (RyR2) have been proposed to account for increased spontaneous calcium release from the ...

Cardiovascular Research, Original Article, Leif Hove-Madsen, Cristina Prat-Vidal, Anna Llach, Francisco Ciruela, Vicent Casadó, Carme Lluis, Antoni Bayes-Genis, Juan Cinca, Rafael Franco

Date : 01/11/2006

Abstract There is much evidence showing that some lethal ventricular arrhythmias arise from waves of Ca2+ release from the sarcoplasmic reticulum (SR) that propagate along cardiac cells. The purpose ...

Cardiovascular Research, Review, Luigi A. Venetucci, Andrew W. Trafford, Stephen C. O'Neill, David A. Eisner

Date : 15/01/2008

Defective EC-coupling in heart failure may result from altered density or function of proteins relevant for calcium homeostasis. Knowledge of these alterations is a prerequisite for understanding ...

Cardiovascular Research, Review, Gerd Hasenfuss

Date : 01/02/1998

Combined potassium and calcium channel antagonistic activities as a basis for neutral frequency dependent increase in action potential duration: comparison between BRL-32872 and azimilide Abstract ...

Cardiovascular Research, Original Article, Antoine Bril, Marie-Claire Forest, Brigitte Cheval, Jean-François Faivre

Date : 01/01/1998

Abstract Objective: This study examines the relative ability of sodium current (INa)-stimulated reverse mode Na/Ca exchange and the L-type calcium current (ICa) to trigger calcium-induced calcium ...

Cardiovascular Research, Original Article, A.M Evans, M.B Cannell

Date : 01/08/1997

Time for primary review 27 days 1 Introduction Heart failure is a syndrome in which dysfunction of the heart causes a mismatch between blood supply and demand of the organs. The pump failure can ...

Cardiovascular Research, Original Article, C Mittmann, T Eschenhagen, H Scholz

Date : 01/08/1998

Abstract Objective: To investigate the effects of stimulating calcium induced Ca release with low concentrations (100200 μM) of caffeine and, in particular, to study the cellular mechanisms ...

Cardiovascular Research, Original Article, A.W Trafford, M.E Dıéaz, D.A Eisner

Date : 01/03/1998

In this issue of the journal, Janssen and colleagues [1] examine the in vitro effects of cyclosporine A (CsA) on myocardial contractile function in multi-cellular preparations obtained from human and ...

Cardiovascular Research, Owen, Virginia J

Date : 01/07/2000