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Abstract Objective: Ca2+ release from the cardiac junctional sarcoplasmic reticulum (SR) is regulated by a complex of proteins, including the ryanodine receptor (RyR), calsequestrin (CSQ), junctin ...

Cardiovascular Research, Original Article, Uwe Kirchhefer, Larry R Jones, Frank Begrow, Peter Boknik, Lutz Hein, Martin J Lohse, Burkhard Riemann, Wilhelm Schmitz, Jörg Stypmann, Joachim Neumann

Date : 01/04/2004 Item size : 335090 bytes

Methods: Antibodies directed against phospholamban and protein markers of the endoplasmic reticulum/Golgi intermediate compartment (ERGIC) and the trans-Golgi were used in fluorescence microscopy ...

Cardiovascular Research, Original Article, John Butler, Anthony G. Lee, David I. Wilson, Cosma Spalluto, Neil A. Hanley, J. Malcolm East

Date : 01/04/2007

Methods: We used formamide-induced detubulation of mouse ventricular myocytes to investigate differential functional distribution and regulation by PKA of α1 and α2 in T-tubule versus SSL ...

Cardiovascular Research, Original Article, Roger G. Berry, Sanda Despa, William Fuller, Donald M. Bers, Michael J. Shattock

Date : 01/01/2007

Abstract Objective: The natriuretic peptides (NPs), atrial (ANP), B-type (BNP), and C-type (CNP) natriuretic peptides as well as their respective receptor-guanylyl cyclases (GC-A for ANP and BNP, and ...

Cardiovascular Research, Original Article, Melanie Pierkes, Stepan Gambaryan, Peter Bokník, Suzanne M. Lohmann, Wilhelm Schmitz, Regine Potthast, Rita Holtwick, Michaela Kuhn

Date : 01/03/2002

Abstract Background: Abnormalities of intracellular calcium handling are widely recognized as a common hallmark of heart failure in animal models and humans. Modifying the interaction of ...

Cardiovascular Research, Original Article, Thomas Dieterle, Markus Meyer, Yusu Gu, Darrell D. Belke, Eric Swanson, Mitsuo Iwatate, John Hollander, Kirk L. Peterson, John Ross, Wolfgang H. Dillmann

Date : 01/09/2005

The human receptor was selected for two reasons: (i) compared to other species, human cardiac muscle exhibits the strongest negative inotropic effect induced by β3-AR agonists [5] and, (ii) ...

Cardiovascular Research, Editorial, Enn K. Seppet

Date : 01/08/2003

Generation of reactive oxygen species (ROS) and cytosolic Ca2+ overload have emerged as two mutually non-exclusive pathogenic mechanisms underlying IR injury [13]. [...]any therapeutic interventions ...

Cardiovascular Research, Original Article, Punam K. Chohan, Raja B. Singh, Naranjan S. Dhalla, Thomas Netticadan

Date : 01/01/2006

Abstract Aims Increased diastolic sarcoplasmic reticulum (SR) Ca2+ loss could depress contractility in heart failure. Since the failing myocardium has impaired energetics, we investigated whether ...

Cardiovascular Research, Original Article, Malle Kuum, Allen Kaasik, Frederic Joubert, Renée Ventura-Clapier, Vladimir Veksler

Date : 01/07/2009

Abstract The cardiac SR Ca2+-ATPase (SERCA2a) regulates intracellular Ca2+-handling and thus, plays a crucial role in initiating cardiac contraction and relaxation. In human heart failure patients, ...

Cardiovascular Research, Review, Konrad F Frank, Birgit Bölck, Erland Erdmann, Robert H.G Schwinger

Date : 01/01/2003

The seminal observation by Furchgott and Zawadzki [1] of a paradoxical vasoconstrictive effect of acetylcholine in arteries deprived of endothelium paved the way for the rapid discovery of nitric ...

Cardiovascular Research, Editorial, Raymond K. Kudej, Christophe Depre

Date : 01/04/2007