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Conclusion: Data show that SR Ca2+ release and SR Ca2+ content were increased in hypertrophied myocytes, despite an increase in the steady state INa/Ca density. The observation that increased SR ...

Cardiovascular Research, Original Article, Alzbeta Chorvatova, George Hart, Munir Hussain

Date : 01/02/2004 Item size : 266773 bytes

To our knowledge, only PMCA mRNA expression was investigated in spontaneously hypertensive rats (SHR)4 and human explanted hearts.5 The lack of evidence concerning transporting activity of PMCA in ...

Cardiovascular Research, Original Article, Urszula Mackiewicz, Michał Maczewski, Anna Konior, James O. Tellez, Dominika Nowis, Halina Dobrzynski, Mark R. Boyett, Bohdan Lewartowski

Date : 15/02/2009 Item size : 282619 bytes

Clinically, chronic systolic LV overload most commonly results from myocardial infarction (MI), or chronic pressure overload, including hypertension and aortic stenosis.1 Despite the apparent ...

Cardiovascular Research, Editorial, Dirk J. Duncker, Elza D. van Deel

Date : 01/03/2012 Item size : 179893 bytes

Keywordsβ2-adrenergic agonistHypertrophyRat, ventricleTime for primary review 31 days. 1 Introduction Previous studies have shown that different stimuli induce cardiac hypertrophy in animals with ...

Cardiovascular Research, Original Article, Kit Wong, Kenneth R Boheler, Jill Bishop, Mario Petrou, Magdi H Yacoub

Date : 01/01/1998 Item size : 264423 bytes

Nonetheless, cardiac remodelling seems to develop in response to increased haemodynamic overload, increased workload, increased ventricular wall tension as well as elevated levels of different ...

Cardiovascular Research, Review, Naranjan S. Dhalla, Harjot K. Saini-Chohan, Delfin Rodriguez-Leyva, Vijayan Elimban, Melissa R. Dent, Paramjit S. Tappia

Date : 15/02/2009 Item size : 566412 bytes

Methods: Antibodies directed against phospholamban and protein markers of the endoplasmic reticulum/Golgi intermediate compartment (ERGIC) and the trans-Golgi were used in fluorescence microscopy ...

Cardiovascular Research, Original Article, John Butler, Anthony G. Lee, David I. Wilson, Cosma Spalluto, Neil A. Hanley, J. Malcolm East

Date : 01/04/2007

Abstract Objective:The immunosuppressive drug Cyclosporine A (CsA) is a key substance in pharmacological therapy following solid organ transplantation and has been suggested to prevent cardiac ...

Cardiovascular Research, Original Article, Paul M.L Janssen, Oliver Zeitz, Boris Keweloh, Ulf Siegel, Lars S Maier, Paul Barckhausen, Burkert Pieske, Jürgen Prestle, Stephan E Lehnart, Gerd ...

Date : 01/07/2000

Abstract Objective: We examined the functional consequences of expressing adult rabbit fast skeletal sarcoplasmic reticulum (SR) Ca2+-ATPase (SERCA1a) in isolated adult rat ventricular ...

Cardiovascular Research, Original Article, Nathalie Chossat, Frank Griscelli, Philippe Jourdon, Damien Logeart, Thierry Ragot, Michèle Heimburger, Michel Perricaudet, Anne-Marie Lompré, ...

Date : 01/02/2001

Pharmacological inhibition of CaMKII-but not of protein kinase A-mediated PLB phosphorylation totally abolished the increased effects of β-adrenergic stimulation on cardiac contractility and ...

Cardiovascular Research, Original Article in Review Focus Series on Calmodulin and Ca, Sevdalina Yurukova, Ana Kilić, Katharina Völker, Kirsten Leineweber, Nataliya Dybkova, Lars S. Maier, ...

Date : 01/03/2007

Throughout development, at least five transcription start sites are used, and no significant difference in the 5 untranslated or 3 coding splice sites could be demonstrated, although several new ...

Cardiovascular Research, Original Article, Maren U Koban, Antoon F.M Moorman, Jurgen Holtz, Magdi H Yacoub, Kenneth R Boheler

Date : 01/02/1998