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Ehjcardiovascrec

Here, we review the current knowledge about the molecular pathophysiology of CPVT and we discuss some potentially innovative strategies for controlling calcium-handling abnormalities in CPVT that may ...

Cardiovascular Research, Review, Nian Liu, Silvia G. Priori

Date : 15/01/2008 Item size : 341044 bytes
Ehjcardiovascrec

The purpose of the present study was to determine whether gender influences the acute electrophysiological actions of genistein at the level of isolated cardiac myocytes and to elucidate the ...

Cardiovascular Research, Original Article, Reginald Liew, Mark A Stagg, Joachim Chan, Peter Collins, Kenneth T MacLeod

Date : 01/01/2004 Item size : 280335 bytes
Ehjcardiovascrec

Introduction Congestive heart failure (CHF) is the leading cause of death in developed countries. Thereby, a better understanding of the cellular and molecular basis of the altered contractility of ...

Cardiovascular Research, Editorial, Stéphane Hatem

Date : 01/04/2004 Item size : 191652 bytes
Ehjcardiovascrec

Acquired and genetic defects in proteins of this junctional Ca2+ signalling complex lead to disease states such as cardiac arrhythmia and heart failure by impairing luminal Ca2+ regulation of ...

Cardiovascular Research, Review, Sandor Györke, Dmitry Terentyev

Date : 15/01/2008 Item size : 422539 bytes
Ehjcardiovascrec

Abstract Objective: We recently reported that doxorubicin (Dox), an effective anti-cancer drug, induces apoptosis in cardiac myocytes in association with reduction of Bcl-xl ...

Cardiovascular Research, Original Article, Keita Kunisada, Eiroh Tone, Shinji Negoro, Yoshikazu Nakaoka, Yuichi Oshima, Tomoaki Osugi, Masanobu Funamoto, Masahiro Izumi, Yasushi Fujio, Hisao Hirota, ...

Date : 01/03/2002 Item size : 258629 bytes
Ehjcardiovascrec

SWAP mice carry two amino acid mutations in NKA-αisoforms so that NKA-α1 is ouabain sensitive and NKA-α2 is ouabain resistant.14 The mutations do not affect the haemodynamic parameters and ...

Cardiovascular Research, Original Article, Sanda Despa, Jerry B. Lingrel, Donald M. Bers

Date : 01/09/2012 Item size : 271019 bytes
Ehjcardiovascrec

Methods: Antibodies directed against phospholamban and protein markers of the endoplasmic reticulum/Golgi intermediate compartment (ERGIC) and the trans-Golgi were used in fluorescence microscopy ...

Cardiovascular Research, Original Article, John Butler, Anthony G. Lee, David I. Wilson, Cosma Spalluto, Neil A. Hanley, J. Malcolm East

Date : 01/04/2007
Ehjcardiovascrec

Abstract Objective: Stimulation of A3 adenosine receptors has been shown to protect cardiac myocytes from ischemic injury, but the mechanism of this action is unknown. Hearts were then homogenized ...

Cardiovascular Research, Original Article, Riccardo Zucchi, Gongyuan Yu, Sandra Ghelardoni, Francesca Ronca, Simonetta Ronca-Testoni

Date : 01/04/2001
Ehjcardiovascrec

During relaxation, Ca2+ is actively transported from the cytosol into the sarcoplasmic reticulum; during contraction, this sequestered Ca2+ is passively released into the cytosol through ...

Cardiovascular Research, Review, Matthew A Movsesian, Robert H.G Schwinger

Date : 01/02/1998
Ehjcardiovascrec

Using novel microscopy and bio-imaging methods researchers have uncovered subtle organization of the control of cyclic adenosine monophosphate (cAMP), the predominant positively inotropic pathway for ...

Cardiovascular Research, SPOTLIGHT REVIEWS: SPOTLIGHT ON T-TUBULES AND RYANODINE RECEPTOR MICRODOMAIN SIGNALLING IN CARDIAC HYPERTROPHY AND FAILURE, Julia Gorelik, Peter T. Wright, Alexander R. Lyon, ...

Date : 01/05/2013