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Ehjcardiovascrec

Three factors combine to the enhanced propensity for the occurrence of delayed afterdepolarizations: (1) increased activity of the Na/Ca exchanger, (2) a reduced inward rectifier, (3) residual ...

Cardiovascular Research, Review, Michiel J Janse

Date : 01/02/2004 Item size : 449802 bytes
Ehjcardiovascrec

Introduction A growing body of evidence in the literature suggests that abnormal channel gating of the sarcoplasmic reticulum (SR) Ca2+ release channel, the cardiac ryanodine receptor (RyR2), is one ...

Cardiovascular Research, Original Article, Makoto Ono, Masafumi Yano, Akihiro Hino, Takeshi Suetomi, Xiaojuan Xu, Takehisa Susa, Hitoshi Uchinoumi, Hiroki Tateishi, Tetsuro Oda, Shinichi Okuda, ...

Date : 01/09/2010 Item size : 255843 bytes
Ehjcardiovascrec

Evidence is now emerging that hyperphosphorylation of the cardiac ryanodine receptor is an important event in chronic heart failure, contributing to impaired contraction and the generation of ...

Cardiovascular Research, Review, Mark Scoote, Alan J Williams

Date : 01/12/2002 Item size : 402108 bytes
Ehjcardiovascrec

Abstract Objectives: To assess the phosphorylation of myocardial phospholamban (PLB) and quantify protein levels of PLB and sarco/endoplasmic reticulum Ca2+ ATPase type 2 (SERCA 2) in a rabbit model ...

Cardiovascular Research, Original Article, Susan Currie, Godfrey L. Smith

Date : 01/01/1999 Item size : 286941 bytes
Ehjcardiovascrec

Methods and results Stereological analysis of transmission electron microscopic images showed that the volume densities and the surface areas of TTs and junctional SRs were both decreased in heart ...

Cardiovascular Research, ORIGINAL ARTICLES: SPOTLIGHT ON T-TUBULES AND RYANODINE RECEPTOR MICRODOMAIN SIGNALLING IN CARDIAC HYPERTROPHY AND FAILURE, Hai-Bo Zhang, Rong-Chang Li, Ming Xu, Shi-Ming Xu, ...

Date : 01/05/2013 Item size : 322473 bytes
Ehjcardiovascrec

Adenovirus mediated gene transfer provides an approach to study functional consequences of SERCA2a overexpression in cardiac myocytes in vitro [1], and a transgenic mouse model allows the effects of ...

Cardiovascular Research, Review, Markus Meyer, Wolfgang H Dillmann

Date : 01/02/1998 Item size : 277106 bytes
Ehjcardiovascrec

Introduction Congestive heart failure (CHF) is the leading cause of death in developed countries. Thereby, a better understanding of the cellular and molecular basis of the altered contractility of ...

Cardiovascular Research, Editorial, Stéphane Hatem

Date : 01/04/2004 Item size : 191652 bytes
Ehjcardiovascrec

Acquired and genetic defects in proteins of this junctional Ca2+ signalling complex lead to disease states such as cardiac arrhythmia and heart failure by impairing luminal Ca2+ regulation of ...

Cardiovascular Research, Review, Sandor Györke, Dmitry Terentyev

Date : 15/01/2008 Item size : 422539 bytes
Ehjcardiovascrec

Abstract Objective: Growth hormone (GH) improves cardiac function in experimental models of heart failure and human dilated cardiomyopathy. Results: Vehicle-treated UM-X7.1 hamsters exhibited ...

Cardiovascular Research, Original Article, Takeshi Ueyama, Tomoko Ohkusa, Masafumi Yano, Masunori Matsuzaki

Date : 01/10/1998 Item size : 287029 bytes
Ehjcardiovascrec

Low ATP content in cardiac tissue was observed in patients with chronic heart failure despite the absence of myocardial ischaemia [1]. Mitochondrial function in cardiac tissue from the failing heart ...

Cardiovascular Research, Editorial, William C Stanley, Charles L Hoppel

Date : 01/03/2000 Item size : 172386 bytes