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Ehjcardiovascrec

Three factors combine to the enhanced propensity for the occurrence of delayed afterdepolarizations: (1) increased activity of the Na/Ca exchanger, (2) a reduced inward rectifier, (3) residual ...

Cardiovascular Research, Review, Michiel J Janse

Date : 01/02/2004 Item size : 449802 bytes
Ehjcardiovascrec

Ucn effects were independent of protein kinase A (PKA) activation but were significantly reduced by protein kinase C (PKC) and mitogen-activated protein kinase (MAPK) inhibitors and by brefeldin A, ...

Cardiovascular Research, Original Article, Eva Calderón-Sanchez, Carmen Delgado, Gema Ruiz-Hurtado, Alejandro Domínguez-Rodríguez, Victoria Cachofeiro, María Rodríguez-Moyano, Ana ...

Date : 01/09/2009 Item size : 303590 bytes
Ehjcardiovascrec

Abstract Aims A sustained, single stretch of a cardiomyocyte activates a transient production of reactive oxygen species by membrane-located NADPH oxidase 2 (Nox2). Additionally, this stretch cycle ...

Cardiovascular Research, ORIGINAL ARTICLES: SPOTLIGHT ON T-TUBULES AND RYANODINE RECEPTOR MICRODOMAIN SIGNALLING IN CARDIAC HYPERTROPHY AND FAILURE, Benjamin L. Prosser, Christopher W. Ward, W. ...

Date : 01/05/2013 Item size : 252479 bytes
Ehjcardiovascrec

In turn, mitochondrial fusion is mediated by two mitofusins (MFN1 and MFN2),2 which are involved in outer membrane fusion, and OPA1 (optic atrophic type 1 protein), which is closely linked to the ...

Cardiovascular Research, Original Article, Jerome Piquereau, Fanny Caffin, Marta Novotova, Alexandre Prola, Anne Garnier, Philippe Mateo, Dominique Fortin, Le Ha Huynh, Valérie Nicolas, Marcel V. ...

Date : 01/06/2012
Ehjcardiovascrec

Recent experimental evidence indicates that activation of the Ca2+/calmodulin-dependent protein kinase II (CaMKII) is an essential step in the sequence of events that increases the Ca2+ transient ...

Cardiovascular Research, Review in Review Focus Series on Calmodulin and Ca, Alicia Mattiazzi, Leticia Vittone, Cecilia Mundiña-Weilenmann

Date : 01/03/2007
Ehjcardiovascrec

[...]despite widespread use of PCI, there has been an increase in the prevalence of ischaemic heart failure, which is mainly attributable to the fact that this treatment has not been as successful as ...

Cardiovascular Research, Editorial, Osamu Tsukamoto, Hiroshi Asanuma, Masafumi Kitakaze

Date : 01/12/2015
Ehjcardiovascrec

LCC are regulated by cytosolic Ca2+, and crosstalk with SR Ca2+ handling occurs on a long-term basis, i.e. during steady-state changes in heart rate, on an intermediate-term basis, i.e. on a ...

Cardiovascular Research, Review, Virginie Bito, Frank R. Heinzel, Liesbeth Biesmans, Gudrun Antoons, Karin R. Sipido

Date : 15/01/2008
Ehjcardiovascrec

The human receptor was selected for two reasons: (i) compared to other species, human cardiac muscle exhibits the strongest negative inotropic effect induced by β3-AR agonists [5] and, (ii) ...

Cardiovascular Research, Editorial, Enn K. Seppet

Date : 01/08/2003
Ehjcardiovascrec

Abstract Objective: We investigated the effect of A1 adenosine receptor overexpression, which has been reported to increase myocardial tolerance to ischemia-reperfusion injury, on sarcoplasmic ...

Cardiovascular Research, Original Article, Riccardo Zucchi, Rachael J Cerniway, Simonetta Ronca-Testoni, R.Ray Morrison, Giovanni Ronca, G.Paul Matherne

Date : 01/02/2002
Ehjcardiovascrec

Abstract Aims During heart failure (HF), the left ventricle (LV) releases B-type natriuretic peptide (BNP), possibly contributing to adverse cardiovascular events including ventricular arrhythmias ...

Cardiovascular Research, Original Article, Jérôme Thireau, Sarah Karam, Jérémy Fauconnier, Stéphanie Roberge, Cécile Cassan, Olivier Cazorla, Franck Aimond, Alain Lacampagne, ...

Date : 01/07/2012