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Abstract Objectives: To assess the phosphorylation of myocardial phospholamban (PLB) and quantify protein levels of PLB and sarco/endoplasmic reticulum Ca2+ ATPase type 2 (SERCA 2) in a rabbit model ...

Cardiovascular Research, Original Article, Susan Currie, Godfrey L. Smith

Date : 01/01/1999 Item size : 286941 bytes

Adenovirus mediated gene transfer provides an approach to study functional consequences of SERCA2a overexpression in cardiac myocytes in vitro [1], and a transgenic mouse model allows the effects of ...

Cardiovascular Research, Review, Markus Meyer, Wolfgang H Dillmann

Date : 01/02/1998 Item size : 277106 bytes

[...]Sp mice exhibited increased atrial ectopy and susceptibility to pacing-induced AF, both of which were also prevented by the RyR2 S2814A mutation. Previously, studies have found that protein ...

Cardiovascular Research, Ion channels and arrhythmias, David Y. Chiang, Na Li, Qiongling Wang, Katherina M. Alsina, Ann P. Quick, Julia O. Reynolds, Guoliang Wang, Darlene Skapura, Niels Voigt, ...

Date : 01/07/2014 Item size : 333015 bytes

[...]altered expression of PLB and SLN has been reported in many cardiac diseases. [...]SERCA2a is a major regulator of intracellular Ca2+ homeostasis, and changes in the expression and activity of ...

Cardiovascular Research, Review, Muthu Periasamy, Poornima Bhupathy, Gopal J. Babu

Date : 15/01/2008 Item size : 520644 bytes

More than a century ago, Traube noted that patients with severe congestive heart failure tend to have alternating strong and weak pulses, or pulsus alternans [8]. [...]mechanical restitution, a ...

Cardiovascular Research, Review, Ronald M Phillips, Prakash Narayan, Ana M Gómez, Keith Dilly, Larry R Jones, W.Jonathan Lederer, Ruth A Altschuld

Date : 01/02/1998

Abstract Objective: Prolonged cardiac contraction and relaxation in hypothyroidism are in part related to diminished expression of the gene coding for the calcium pump of the sarcoplasmic reticulum ...

Cardiovascular Research, Original Article, Wolfgang F. Bluhm, Markus Meyer, M.Richard Sayen, Eric A. Swanson, Wolfgang H. Dillmann

Date : 01/08/1999

Abstract Objective: The activity of sarcoplasmic reticulum Ca2+-ATPase (SERCA) is reduced in the failing myocardium. [...]transfer of SERCA2a cDNA is considered as a therapeutical ...

Cardiovascular Research, Original Article, Oliver J. Müller, Mathias Lange, Henning Rattunde, Hans-Peter Lorenzen, Matthias Müller, Norbert Frey, Cordula Bittner, Warner Simonides, Hugo A. ...

Date : 01/08/2003

Methods: Subepicardial (epi), midmyocardial (mid), and subendocardial (endo) sections of the left ventricular free wall from end-stage failing (n=17) and nonfailing (n=5) human hearts were analyzed ...

Cardiovascular Research, Original Article, Jürgen Prestle, Sabine Dieterich, Michael Preuss, Ursula Bieligk, Gerd Hasenfuss

Date : 01/08/1999

Abstract Objective: Left ventricular assist device support mechanically unloads the failing ventricle with resultant improvement in cardiac geometry and function in patients with end-stage heart ...

Cardiovascular Research, Original Article, Yasuchika Takeishi, Thunder Jalili, Brian D. Hoit, Darryl L. Kirkpatrick, Lynne E. Wagoner, William T. Abraham, Richard A. Walsh

Date : 01/03/2000

KeywordsCalcium (cellular)Genetic codeHeart failureSR (function)Ventricular function 1 Introduction The mammalian organism responds to chronic pressure and volume overload of the heart with a ...

Cardiovascular Research, Update review, U Ravens, D Dobrev

Date : 01/01/2000