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Abstract Objectives: This study aims at clarifying the role of cellular Ca2+ overload and spontaneous sarcoplasmic reticulum (SR) Ca2+ release in the generation of early afterdepolarizations (EAD) by ...

Cardiovascular Research, Original Article, Paul G.A Volders, Attila Kulcsár, Marc A Vos, Karin R Sipido, Hein J.J Wellens, Ralph Lazzara, Bela Szabo

Date : 01/05/1997 Item size : 219807 bytes

Methods and results Repeated Ca2+ sparks were induced from individual clusters of ryanodine receptors (RyRs) in quiescent rat ventricular myocytes, and we examined how changes in RyR gating ...

Cardiovascular Research, Original Article, Hena R. Ramay, Ona Z. Liu, Eric A. Sobie

Date : 01/09/2011 Item size : 285833 bytes

The purpose of the present study was to determine whether gender influences the acute electrophysiological actions of genistein at the level of isolated cardiac myocytes and to elucidate the ...

Cardiovascular Research, Original Article, Reginald Liew, Mark A Stagg, Joachim Chan, Peter Collins, Kenneth T MacLeod

Date : 01/01/2004 Item size : 280335 bytes

To our knowledge, only PMCA mRNA expression was investigated in spontaneously hypertensive rats (SHR)4 and human explanted hearts.5 The lack of evidence concerning transporting activity of PMCA in ...

Cardiovascular Research, Original Article, Urszula Mackiewicz, Michał Maczewski, Anna Konior, James O. Tellez, Dominika Nowis, Halina Dobrzynski, Mark R. Boyett, Bohdan Lewartowski

Date : 15/02/2009 Item size : 282619 bytes

Introduction Congestive heart failure (CHF) is the leading cause of death in developed countries. Thereby, a better understanding of the cellular and molecular basis of the altered contractility of ...

Cardiovascular Research, Editorial, Stéphane Hatem

Date : 01/04/2004 Item size : 191652 bytes

The potential relevance of increased incidence of spontaneous SR Ca2+ release for both AF induction and/or maintenance and the development of novel mechanism-based therapeutic approaches will be ...

Cardiovascular Research, REVIEWS: FOCUS ON THE MOLECULAR BASIS OF ATRIAL FIBRILLATION, Dobromir Dobrev, Niels Voigt, Xander H.T. Wehrens

Date : 01/03/2011 Item size : 506157 bytes

Conclusion: These results suggest that the attenuation of IGF-1-induced cardiac contractile response in chemically-induced diabetes also exists in diabetes of genetic origin, possibly due to ...

Cardiovascular Research, Original Article, Jun Ren

Date : 01/04/2000

Abstract Background: Alterations in the cyclic AMP-dependent regulation of the cardiac ryanodine receptor (RyR2) have been proposed to account for increased spontaneous calcium release from the ...

Cardiovascular Research, Original Article, Leif Hove-Madsen, Cristina Prat-Vidal, Anna Llach, Francisco Ciruela, Vicent Casadó, Carme Lluis, Antoni Bayes-Genis, Juan Cinca, Rafael Franco

Date : 01/11/2006

Abstract Objectives: Characterization of an in vitro model of endothelin-1 induced hypertrophy of cultured neonatal rat ventricular myocytes and subsequent analysis of transcription regulation of the ...

Cardiovascular Research, Original Article, Han A.A. van Heugten, Marga C. van Setten, Karin Eizema, Pieter D. Verdouw, Jos M.J. Lamers

Date : 01/02/1998

Abstract Cardiac sarcolemmal Na+Ca2+ exchange is a central component of Ca2+ signaling essential for Ca2+ extrusion and contributing to a variable degree to the development of the systolic Ca2+ ...

Cardiovascular Research, Review, Hannes Reuter, Christian Pott, Joshua I. Goldhaber, Scott A. Henderson, Kenneth D. Philipson, Robert H.G. Schwinger

Date : 01/08/2005