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Introduction Proprotein convertase subtilisin/kexin type 9 (PCSK9) increases plasma low-density lipoprotein (LDL) cholesterol (LDL-C) by acting as a ligand for hepatic LDL receptors (LDLR), targeting ...

Cardiovascular Research, Original Article, Hagai Tavori, Ilaria Giunzioni, Irene M. Predazzi, Deanna Plubell, Anna Shivinsky, Joshua Miles, Rachel M. Devay, Hong Liang, Shirya Rashid, MacRae F. ...

Date : 15/05/2016 Item size : 404061 bytes

Introduction Recent studies have reported the existence of multiple stem cell populations in the mammalian heart.17 Despite this, the rate of cardiomyocyte renewal is extremely low and declines ...

Cardiovascular Research, Cardiac biology and remodelling, Wen-Pin Chen, Yuan-Hung Liu, Yi-Jin Ho, Sean M. Wu

Date : 01/01/2015 Item size : 29787 bytes

A vicious cycle of inflammation and further oxidative stress results in increased endothelial permeability to lipoproteins and monocytes, and ultimately to atherosclerotic plaque development.1 ...

Cardiovascular Research, Vascular biology, Hayley Mylroie, Odile Dumont, Andrea Bauer, Clare C. Thornton, John Mackey, Damien Calay, Shahir S. Hamdulay, Joan R. Choo, Joseph J. Boyle, Allen M. ...

Date : 01/06/2015 Item size : 397507 bytes

The mouse has turned out to be an invaluable model for mammalian genetic modifications to mimic and analyse cardiovascular pathology. KeywordsPhenotypeMouseGene ...

Cardiovascular Research, Review, Pieter A Doevendans, Mat J. Daemen, Ebo D de Muinck, Jos F Smits

Date : 01/07/1998 Item size : 533368 bytes

Abstract Objective Neointimal formation following percutaneous coronary intervention (PCI), termed restenosis, limits therapeutic revascularization. Since reendothelialization is one of the ...

Cardiovascular Research, Original Article, Toru Yoshioka, Masafumi Takahashi, Yuji Shiba, Chihiro Suzuki, Hajime Morimoto, Atsushi Izawa, Hirohiko Ise, Uichi Ikeda

Date : 01/04/2006 Item size : 268108 bytes

Methods: A cardiac MyBP-C cDNA lacking nine amino acids, which contained a phosphorylation site, was made, and subsequently used to generate multiple lines of transgenic mice. Upon confirming that a ...

Cardiovascular Research, Original Article, Qinglin Yang, Timothy E. Hewett, Raisa Klevitsky, Atsushi Sanbe, Xuejun Wang, Jeffrey Robbins

Date : 01/07/2001 Item size : 259175 bytes

Abstract The endocrine function of the heart was shown by the identification of a potent inhibitor of renal tubular NaCl reabsorbtion, atrial natriuretic peptide/factor (ANP), in atrial ...

Cardiovascular Research, Review, Arjan C. Houweling, Marcel M. van Borren, Antoon F.M. Moorman, Vincent M. Christoffels

Date : 01/09/2005 Item size : 428573 bytes

Abstract Objective: The aim of this work was to target a vital reporter gene in the mouse cardiac conduction system (CS) to distinguish this tissue from the surrounding myocardium in the adult ...

Cardiovascular Research, Original Article, Lucile Miquerol, Sonia Meysen, Matteo Mangoni, Patrick Bois, Harold V.M van Rijen, Patrice Abran, Habo Jongsma, Joël Nargeot, Daniel Gros

Date : 01/07/2004 Item size : 273439 bytes

Abstract Objective Dilated cardiomyopathy (DCM) leads to dilation of the cardiac chambers and congestive heart failure. The Snail family of zinc finger proteins are transcriptional repressors that ...

Cardiovascular Research, Original Article, Michael Hesse, Colleen S. Kondo, Robert B. Clark, Lin Su, Frances L. Allen, Colleen T.M. Geary-Joo, Stanley Kunnathu, David L. Severson, Anders Nygren, ...

Date : 01/08/2007 Item size : 291044 bytes

The transcription of a gene is controlled by transcription factors that interact with cis-elements present in unique combinations in regulatory DNA sequences of the gene. Analyses of transgenic mice ...

Cardiovascular Research, Review, Petra E.M.H. Habets, Antoon F.M. Moorman, Vincent M. Christoffels

Date : 01/05/2003 Item size : 451931 bytes