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Abstract Aims Stimulation of β-adrenergic receptors (β-AR) increases cAMP production and contributes to the pathogenesis of cardiac hypertrophy and failure through poorly understood ...

Cardiovascular Research, Cardiac biology and remodelling, Anne-Coline Laurent, Malik Bisserier, Alexandre Lucas, Florence Tortosa, Marie Roumieux, Annélie De Régibus, Audrey Swiader, Yannis ...

Date : 01/01/2015 Item size : 311173 bytes

Introduction Efficiency of excitationcontraction in the adult ventricular myocyte is enhanced by the structural features of this highly organised cell, with its scalloped surface formed by periodic ...

Cardiovascular Research, Original Article, Julia Gorelik, Lin Q. Yang, Yanjun Zhang, Max Lab, Yuri Korchev, Sian E. Harding

Date : 01/12/2006 Item size : 223827 bytes

Results: FCCP (10-1000 nM) caused significant dose-dependent increase in oxygen consumption. Introduction It is now clear that mitochondria are not only the site of oxidative phosphorylation and ...

Cardiovascular Research, Original Article, Jonathan P. Brennan, Roger G. Berry, Max Baghai, Michael R. Duchen, Michael J. Shattock

Date : 01/11/2006 Item size : 260354 bytes

Abstract Objectives: This study aims at clarifying the role of cellular Ca2+ overload and spontaneous sarcoplasmic reticulum (SR) Ca2+ release in the generation of early afterdepolarizations (EAD) by ...

Cardiovascular Research, Original Article, Paul G.A Volders, Attila Kulcsár, Marc A Vos, Karin R Sipido, Hein J.J Wellens, Ralph Lazzara, Bela Szabo

Date : 01/05/1997 Item size : 219807 bytes

Abstract Objective In vitro experiments have shown that the ryanodine receptor-2 (RyR2) central domain peptide DPc10 (Gly2460-Pro2495) mimics channel dysfunction associated with catecholaminergic ...

Cardiovascular Research, Original Article, Zhaokang Yang, Noriaki Ikemoto, Graham D. Lamb, Derek S. Steele

Date : 01/06/2006 Item size : 251644 bytes

Abstract Objective: Contractions of isolated, single myocytes of guinea pig heart stimulated at 37°C consist of a phasic component and a voltage dependent tonic component. Conclusions: Tonic ...

Cardiovascular Research, Original Article, Krzysztof Emanuel, Urszula Mackiewicz, Bohdan Lewartowski

Date : 01/10/2001 Item size : 253435 bytes

In the heart, NO is produced by neuronal and endothelial NO synthase (nNOS and eNOS), which are constitutively expressed in cardiomyocytes and playing specific roles on the modulation of contractile ...

Cardiovascular Research, Original Article, Qian-Chen Yong, Li-Fang Hu, Suhua Wang, Dejian Huang, Jin-Song Bian

Date : 01/12/2010 Item size : 331095 bytes

Methods: We determined the role of Rho and Rho-associated kinase (ROCK) as mediators of leptin-induced cell hypertrophy in cultured neonatal rat ventricular myocytes. The physiological effects of ...

Cardiovascular Research, Original Article, Asad Zeidan, Sabzali Javadov, Morris Karmazyn

Date : 01/10/2006 Item size : 299645 bytes

Receptors for S1P are also present in endothelial and smooth muscle cells where they mediate peripheral vascular tone and endothelial responses, but the role of this regulatory system in the cardiac ...

Cardiovascular Research, Review, Christopher K. Means, Joan Heller Brown

Date : 01/05/2009 Item size : 471982 bytes

Abstract Objective: To compare the properties of single myocytes isolated from different layers of the basal region of the left ventricle and to test the hypothesis that differences in the delayed ...

Cardiovascular Research, Original Article, Simon M. Bryant, Xiaoping Wan, S.Jane Shipsey, George Hart

Date : 01/11/1998 Item size : 282677 bytes