Rare genetic mutations that cause reduced LDL receptor function lead to markedly higher LDL-C and a dose-dependent increase in the risk of ASCVD, whereas rare variants leading to lower LDL-C are ...

European Heart Journal, Ference, Brian A., Ginsberg, Henry N., Graham, Ian, Ray, Kausik K., Packard, Chris J., Bruckert, Eric, Hegele, Robert A., Krauss, Ronald M., Raal, Frederick J., Schunkert, ...