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Ehjournal

Presently available treatment options are far from optimal and new insights into underlying mechanisms are needed to improve therapy. The objective of the present paper is to review the ...

European Heart Journal, Nattel, Stanley, Dobrev, Dobromir

Date : 01/08/2012
Ehjournal

Vagal stimulation shortens atrial APD and ERP and increases dispersion of atrial ERPs.2 This creates an arrhythmogenic substrate for re-entry of the excitation wave front which may allow the ...

European Heart Journal, Dobrev, Dobromir, Christ, Torsten, Ravens, Ursula

Date : 01/07/2004
Ehjournal

Vagal stimulation shortens atrial APD and ERP and increases dispersion of atrial ERPs.2 This creates an arrhythmogenic substrate for re-entry of the excitation wave front which may allow the ...

European Heart Journal, Dobrev, Dobromir, Christ, Torsten, Ravens, Ursula

Date : 01/07/2004 Item size : 102996 bytes
Ehjcardiovascrec

In atrial fibrillation (AF), the high atrial rate abbreviates the atrial action potential duration primarily by reduced ICa,L and increased inward-rectifier K+ currents like the background current ...

Cardiovascular Research, Dobrev, Dobromir, Wettwer, Erich

Date : 01/06/2008 Item size : 125314 bytes
Ehjournal

Guidelines, Atrial fibrillation, Anticoagulation, Vitamin K antagonists, Non-vitamin K antagonist oral anticoagulants, Left atrial appendage occlusion, Rate control, Cardioversion, Rhythm control, ...

European Heart Journal, Kirchhof, Paulus, Benussi, Stefano, Kotecha, Dipak, Ahlsson, Anders, Atar, Dan, Casadei, Barbara, Castella, Manuel, Diener, Hans-Christoph, Heidbuchel, Hein, Hendriks, Jeroen, ...

Date : 07/10/2016
Ehjournal

Fatini et al.2 provide evidence that susceptibility to non-valvular AF (NVAF) may be enhanced in association with certain single nucleotide polymorphisms in the genes encoding the accessory K+ ...

European Heart Journal, Dobrev, Dobromir, Ravens, Ursula

Date : 02/07/2006
Ehjcardiovascrec

[...]the therapeutic potential of I-1 in heart failure and arrhythmias has recently been addressed by the generation and analysis of several I-1 genetic mouse models. Introduction The prevalence of ...

Cardiovascular Research, Wittköpper, Katrin, Dobrev, Dobromir, Eschenhagen, Thomas, El-Armouche, Ali

Date : 01/08/2011 Item size : 429005 bytes
Ehjcardiovascrec

Atrial fibrillation (AF), the most common sustained arrhythmia, is associated with substantial cardiovascular morbidity and mortality, with stroke being the most critical complication.1 Present drugs ...

Cardiovascular Research, Dobrev, Dobromir, Nattel, Stanley

Date : 01/03/2011 Item size : 158514 bytes
Ehjcardiovascrec

[...]Sp mice exhibited increased atrial ectopy and susceptibility to pacing-induced AF, both of which were also prevented by the RyR2 S2814A mutation. Previously, studies have found that protein ...

Cardiovascular Research, Chiang, David Y., Li, Na, Wang, Qiongling, Alsina, Katherina M., Quick, Ann P., Reynolds, Julia O., Wang, Guoliang, Skapura, Darlene, Voigt, Niels, Dobrev, Dobromir, Wehrens, ...

Date : 01/07/2014
Ehjcardiovascrec

The potential relevance of increased incidence of spontaneous SR Ca2+ release for both AF induction and/or maintenance and the development of novel mechanism-based therapeutic approaches will be ...

Cardiovascular Research, Dobrev, Dobromir, Voigt, Niels, Wehrens, Xander H.T.

Date : 01/03/2011 Item size : 490642 bytes