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Calpain activity correlated with L-type Ca2+ channel and Kv1.5 protein amounts (r=0.80, P<0.001 and r=0.72, P<0.001, respectively), degree of structural changes (r=0.90, P<0.001), shortening of ...

Cardiovascular Research, Original Article, Bianca J.J.M Brundel, Jannie Ausma, Isabelle C van Gelder, Johan J.L Van Der Want, Wiek H van Gilst, Harry J.G.M Crijns, Robert H Henning

Date : 01/05/2002 Item size : 282302 bytes

Abstract Objective: Prolonged atrial fibrillation (AF) results in (ultra)structural remodelling of atrial cardiomyocytes resembling alterations seen in ischemia-induced ventricular hibernation. In ...

Cardiovascular Research, Original Article, Jannie Ausma, Will A Coumans, Hans Duimel, Ger J Van der Vusse, Maurits A Allessie, Marcel Borgers

Date : 01/09/2000

The authors report that in biopsies from patients with AF, concomitantly suffering from valvular disease, the majority of atrial myocytes undergo changes which are reminiscent of dedifferentiation, ...

Cardiovascular Research, Editorial, Jannie Ausma, Marcel Borgers

Date : 01/07/2002

Atrial structural remodeling also occurs as a result of heart failure and other underlying cardiovascular diseases. The associated atrial fibrosis might explain intra-atrial conduction disturbances ...

Cardiovascular Research, Review, Maurits Allessie, Jannie Ausma, Ulrich Schotten

Date : 01/05/2002

In patients with paroxysmal or persistent AF reduced protein levels of L-type Ca2+ channel were shown to correlate with AERP shortening [5]. Besides the L-type Ca2+ channel, the expression of ...

Cardiovascular Research, Original Article, Victor L.J.L Thijssen, Huub M.W van der Velden, Erwin P van Ankeren, Jannie Ausma, Maurits A Allessie, Marcel Borgers, Guillaume J.J.M van Eys, Habo J ...

Date : 01/05/2002

Abstract Objective: It has been postulated that high atrial rate induced changes at the level of the gap junctions (gap junctional remodeling i.e. changes in distribution, intercellular orientation ...

Cardiovascular Research, Original Article, Huub M.W. van der Velden, Jannie Ausma, Martin B. Rook, Anita J.C.G.M. Hellemons, Toon A.A.B. van Veen, Maurits A. Allessie, Habo J. Jongsma

Date : 01/06/2000

Both phenomena are reversible but after prolonged duration of atrial fibrillation, a discrepancy occurs between rapid electrical remodelling and slow recovery of contractile function. In ...

Cardiovascular Research, Review, Victor L.J.L. Thijssen, Jannie Ausma, Marcel Borgers

Date : 01/10/2001