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Abstract Aims The chemokine receptor CXCR4 modulates endothelial progenitor cell migration, homing, and differentiation, and plays a key role in cardiovascular regeneration. In a mouse model of ...

European Heart Journal, Cencioni, Chiara, Melchionna, Roberta, Straino, Stefania, Romani, Marta, Cappuzzello, Claudia, Annese, Valentina, Wu, Joseph C., Pompilio, Giulio, Santoni, Angela, Gaetano, ...

Date : 07/07/2013 Item size : 323914 bytes

Atherosclerosis is initiated by dysfunction of endothelial cells (ECs), leading to expression of adhesion molecules for inflammatory cells.1,2 Vascular inflammation leads to an oxidizing environment ...

European Heart Journal, Satoh, Kimio, Shimokawa, Hiroaki

Date : 14/07/2014 Item size : 164245 bytes

Among CD4+T cells, Th 1 cells have been shown to exert proatherogenic effects, whereas regulatory T cells (Treg) display atheroprotective properties and the role of Th2 and Th17 cells remains ...

Cardiovascular Research, Taleb, Soraya, Tedgui, Alain

Date : 01/06/2015

Methods and results The effects of locally injected S1P on blood flow recovery, angiogenesis, and vascular permeability in mouse ischaemic hindlimbs that underwent femoral arteriectomy were assessed ...

Cardiovascular Research, Oyama, Osamu, Sugimoto, Naotoshi, Qi, Xun, Takuwa, Noriko, Mizugishi, Kiyomi, Koizumi, Junji, Takuwa, Yoh

Date : 01/05/2008 Item size : 260804 bytes

Introduction The development of new blood vessels is essential to embryonic growth and throughout life for physiological repair processes such as wound healing, post-ischaemic tissue restoration, and ...

European Heart Journal, Felmeden, D.C, Blann, A.D, Lip, G.Y.H

Date : 01/04/2003 Item size : 419779 bytes

PKCζ mediates the induction of NADPH oxidase by transforming growth factor-α in endothelial cells.3 Interestingly, PKCα seems to mediate inhibitory effects on the superoxide generation by ...

Cardiovascular Research, Graf, Kristof

Date : 01/06/2008

Since the 1970's a link between infectious disease and atherosclerotic disease has been hypothesized [13]. Infectious agents that are implicated in the pathogenesis of atherosclerosis include ...

Cardiovascular Research, Levi, Marcel

Date : 01/06/2001

Because of a rather fluid transition between therapeutic and toxic concentrations of CTS, i.e. a narrow therapeutic window, severe toxicity as a result of overdose is not uncommon. Cardiotonic ...

Cardiovascular Research, Scheiner-Bobis, Georgios

Date : 01/01/2011 Item size : 167120 bytes

Inflammation in atherosclerosis Today, multiple different pieces of evidence set inflammation as a key pathogenetic mechanism in the development of atherosclerosis and its complications.14 A better ...

Cardiovascular Research, Elhage, Rima, Ljunggren, Hans-Gustaf, Hansson, Göran K.

Date : 01/11/2012 Item size : 295184 bytes

In less than 15 years, an explosion of interest in angiogenesis research has generated the necessary insights to develop the first clinically approved anti-angiogenic agents.1 Several additional ...

Cardiovascular Research, Silvestre, Jean-Sebastien, Lévy, Bernard I., Tedgui, Alain

Date : 01/05/2008 Item size : 139382 bytes