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Abstract Pulmonary hypertension (PH) is the end result of interaction between pulmonary vascular tone and a complex series of cellular and molecular events termed vascular remodelling The remodelling ...

Cardiovascular Research, Stenmark, Kurt R, Frid, Maria G, Graham, Brian B, Tuder, Rubin M

Date : 15/03/2018 Item size : 664453 bytes

Fibroblast growth factor-2 (FGF-2) plays an instructive role in osteogenesis and bone development, but its role in vascular calcification was unknown. [...]we investigated the involvement of FGF-2 ...

Cardiovascular Research, Borland, Samantha J., Morris, Thomas G., Borland, Shona C., Morgan, Mark R., Francis, Sheila E., Merry, Catherine L.R., Canfield, Ann E.

Date : 01/11/2017 Item size : 371746 bytes

Introduction Hypertension is associated with vascular changes characterized by endothelial dysfunction, increased vascular contraction, and arterial remodelling.13 Vascular smooth muscle cells, which ...

Cardiovascular Research, Touyz, Rhian M, Alves-Lopes, Rheure, Rios, Francisco J, Camargo, Livia L, Anagnostopoulou, Aikaterini, Arner, Anders, Montezano, Augusto C

Date : 15/03/2018 Item size : 543415 bytes

Introduction Based on morphological studies performed in the sixties it was clearly demonstrated that the smooth muscle cell (SMC) is the unique cell type found in medial layer of arteries (reviewed ...

Cardiovascular Research, Bochaton-Piallat, Marie-Luce, Bäck, Magnus

Date : 15/03/2018 Item size : 156761 bytes

Abstract Arterial aging engages a plethora of key signalling pathways that act in concert to induce vascular smooth muscle cell (VSMC) phenotypic changes leading to vascular degeneration and ...

Cardiovascular Research, Lacolley, Patrick, Regnault, Veronique, Avolio, Alberto P

Date : 15/03/2018 Item size : 691720 bytes

Abstract Aims Reactive oxygen species (ROS) play essential roles in the pulmonary vascular remodelling associated with hypoxia-induced pulmonary hypertension (PH). Furthermore, a hypoxia-induced PH ...

Cardiovascular Research, You, Baiyang, Liu, Yanbo, Chen, Jia, Huang, Xiao, Peng, Huihui, Liu, Zhaoya, Tang, Yixin, Zhang, Kai, Xu, Qian, Li, Xiaohui, Cheng, Guangjie, Shi, Ruizheng, Zhang, Guogang

Date : 01/01/2018 Item size : 393213 bytes

In patients who experience an acute myocardial infarction (AMI), a greater extent of myocardial necrosis results in a worse long-term prognosis.1 It is therefore imperative to develop treatments that ...

Cardiovascular Research, Davidson, Sean M, Yellon, Derek M

Date : 01/05/2018 Item size : 157882 bytes

[...]medial calcification is linked to vessel stiffness, systolic hypertension, and increased pulse wave velocity leading to increased diastolic dysfunction and heart failure.2 Whilst originally ...

Cardiovascular Research, Durham, Andrew L, Speer, Mei Y, Scatena, Marta, Giachelli, Cecilia M, Shanahan, Catherine M

Date : 15/03/2018 Item size : 543243 bytes