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Studies in small and large animal ischaemic heart disease models have reported that myocardial overexpression of VEGF following naked DNA transfection, Ad vectors, or AAV transduction induce ...

Cardiovascular Research, Review, Melvin Y. Rincon, Thierry VandenDriessche, Marinee K. Chuah

Date : 01/10/2015 Item size : 834056 bytes

[...]re-endothelialization is not always complete and often dysfunctional. [...]the molecular and biomechanical mechanisms that control EC repair and function in stented segments are poorly ...

Cardiovascular Research, SPOTLIGHT REVIEWS: SPOTLIGHT ON BIOMECHANICAL FACTORS IN CARDIOVASCULAR DISEASE, Kim Van der Heiden, Frank J. H. Gijsen, Andrew Narracott, Sarah Hsiao, Ian Halliday, Julian ...

Date : 15/07/2013 Item size : 450524 bytes

The prevalence of AF increases markedly with advancing age.1,2 AF is associated with multiple complications including dementia, heart failure, and stroke.38 AF is also associated with a significant ...

Cardiovascular Research, TOPICAL REVIEWS, Saagar Mahida

Date : 01/02/2014 Item size : 544484 bytes

1 Introduction When surveying the literature with the intention of evaluating to which extent studies on animal models have contributed to the understanding of arrhythmia mechanisms in patients and ...

Cardiovascular Research, Review, Michiel J. Janse, Tobias Opthof, André G. Kléber

Date : 01/07/1998 Item size : 562183 bytes

An ideal animal model for any cardiovascular disease in humans should have five characteristics: (i) mimic the human disease, (ii) allow studies in chronic, stable disease, (iii) produce symptoms ...

Cardiovascular Research, Review, Sheila A Doggrell, Lindsay Brown

Date : 01/07/1998 Item size : 693819 bytes

The widely used model is the spontaneous hypertensive rat (SHR) with a polygenic determination of hypertension has been a useful tool for the study of pathophysiological alterations in hypertensive ...

Cardiovascular Research, Original Article, Oliver Zolk, Markus Flesch, Georg Nickenig, Petra Schnabel, Michael Böhm

Date : 01/07/1998 Item size : 587738 bytes

The formation of a novel vascular network is a rare event in the adult organism and occurs in a tightly controlled and transient manner in the female reproductive organs. Neovascularization occurs ...

Cardiovascular Research, Review, Guido Melillo, Marco Scoccianti, Imre Kovesdi, Jorge Safi, Teresa Riccioni, Maurizio C Capogrossi

Date : 01/09/1997 Item size : 507540 bytes

Three factors combine to the enhanced propensity for the occurrence of delayed afterdepolarizations: (1) increased activity of the Na/Ca exchanger, (2) a reduced inward rectifier, (3) residual ...

Cardiovascular Research, Review, Michiel J Janse

Date : 01/02/2004 Item size : 449802 bytes

Pulmonary arterial hypertension (PAH) is a severe condition characterized by a progressive increase in pulmonary vascular resistance leading to right ventricular failure and death. An activation of ...

Cardiovascular Research, Review, Nazzareno Galié, Alessandra Manes, Angelo Branzi

Date : 01/02/2004 Item size : 434770 bytes

For a detailed consideration of physiological vs. pathological hypertrophy (see Dorn, 2007).], resulting from volume overload-induced cardiomyocyte lengthening, without activation of foetal genes3 ...

Cardiovascular Research, Review, Elizabeth A. Woodcock, Xiao-Jun Du, Melissa E. Reichelt, Robert M. Graham

Date : 01/02/2008 Item size : 499739 bytes