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ULK1 phosphorylation at Ser757 and Ser777 was down-regulated and up-regulated, respectively, by ethanol, the effect of which was nullified by AMPK deficiency or inhibition. [...]the ethanol ...

Cardiovascular Research, Guo, Rui, Ren, Jun

Date : 01/06/2012

Abstract Objective The purpose of the present study was to determine whether increased activation of the RhoA/Rho-kinase (ROCK) pathway occurs in diabetic cardiomyopathy and whether acute inhibition ...

Cardiovascular Research, Lin, Guorong, Craig, Graham P., Zhang, Lili, Yuen, Violet G., Allard, Michael, McNeill, John H., MacLeod, Kathleen M.

Date : 01/07/2007 Item size : 275933 bytes

Abstract Decreased amplitude and slower kinetics of cardiomyocyte intracellular calcium (Cai2+) transients may underlie the diminished cardiac function observed in heart failure. Objective: Since ...

Cardiovascular Research, Janczewski, Andrzej M, Zahid, Maliha, Lemster, Bonnie H, Frye, Carol S, Gibson, Gregory, Higuchi, Yoshihiro, Kranias, Evangelia G, Feldman, Arthur M, McTiernan, Charles F

Date : 01/06/2004

Abstract Aims Recent studies from our laboratory demonstrated that increased expression of the small GTP-binding protein RhoA and activation of the RhoA/rho kinase (ROCK) pathway play an important ...

Cardiovascular Research, Soliman, Hesham, Craig, Graham P., Nagareddy, Prabhakar, Yuen, Violet G., Lin, Guorong, Kumar, Ujendra, McNeill, John H., MacLeod, Kathleen M.

Date : 15/07/2008

Several studies, including investigations in humans, have clearly shown an important pathophysiological role of this pathway in the cardiovascular system and in disease states such as hypertension, ...

Cardiovascular Research, Peters, Stephan L.M., Michel, Martin C.

Date : 01/07/2007 Item size : 127140 bytes

Time for primary review 33 days. 1 Introduction Heart failure was defined by Braunwald as the pathophysiologic state of impaired cardiac function rendering the heart unable to maintain an output ...

Cardiovascular Research, Hein, Stefan, Kostin, Sawa, Heling, Annette, Maeno, Yoshi, Schaper, Jutta

Date : 14/01/2000

Abstract Objective: We have previously shown that cardiac-directed expression of adenylycyclase type VI (ACVI) increases heart function in transgenic mice, and improves heart function and survival in ...

Cardiovascular Research, Gao, Mei Hua, Bayat, Hamed, Roth, David M, Yao Zhou, Jin, Drumm, Jeffrey, Burhan, John, Kirk Hammond, H

Date : 01/11/2002 Item size : 246209 bytes

For a detailed consideration of physiological vs. pathological hypertrophy (see Dorn, 2007).], resulting from volume overload-induced cardiomyocyte lengthening, without activation of foetal genes3 ...

Cardiovascular Research, Woodcock, Elizabeth A., Du, Xiao-Jun, Reichelt, Melissa E., Graham, Robert M.

Date : 01/02/2008 Item size : 462733 bytes

Understanding the signaling mechanisms of these receptors in the context of the heart is likely to provide a better therapeutic approach towards treatment of heart failure. 1. Introduction ...

Cardiovascular Research, Barki-Harrington, Liza, Perrino, Cinzia, Rockman, Howard A

Date : 15/08/2004 Item size : 492497 bytes

Abstract Objective: The aim of this study was to test the hypothesis that, shortly after the development of Type-2 diabetes, alterations in cardiac carbohydrate metabolism precede the onset of ...

Cardiovascular Research, Chatham, John C, Seymour, Anne-Marie L

Date : 01/07/2002 Item size : 312441 bytes