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Ehjournal

Selection of individuals for genetic testing for familial hypercholesterolaemia: development and external validation of a prediction model for the presence of a mutation causing familial ...

European Heart Journal, Besseling, Joost, Reitsma, Johannes B., Gaudet, Daniel, Brisson, Diane, Kastelein, John J.P., Hovingh, G. Kees, Hutten, Barbara A.

Date : 21/02/2017
Ehjournal

[...]a substantial number of statin-treated patients who are in the recommended range of low-density lipoprotein cholesterol (LDL-C) levels still develop cardiovascular events.1,2 One of the markers ...

European Heart Journal, Sondermeijer, Brigitte M., Boekholdt, S. Matthijs, Rana, Jamal S., Kastelein, John J.P., Wareham, Nicholas J., Khaw, Kay-Tee

Date : 07/05/2013 Item size : 200584 bytes
Ehjournal

Rather, they do so to better target therapy and improve the lives of their patients. [...]when considering the use of any biomarker for cardiovascular risk prediction in primary prevention, ...

European Heart Journal, Ridker, Paul M, Kastelein, John J.P., Genest, Jacques, Koenig, Wolfgang

Date : 01/05/2013 Item size : 180317 bytes
Ehjcardiovascrec

Abstract Objective: Dihydropyridine calcium antagonists have been shown to retard atherogenesis in animal models and to prevent the development of early angiographic lesions in human coronary ...

Cardiovascular Research, Verhaar, Marianne C., Honing, Marina L.H., van Dam, Thea, Zwart, Mirjam, Koomans, Hein A., Kastelein, John J.P., Rabelink, Ton J.

Date : 01/06/1999
Ehjournal

[...]a substantial number of statin-treated patients who are in the recommended range of low-density lipoprotein cholesterol (LDL-C) levels still develop cardiovascular events.1,2 One of the markers ...

European Heart Journal, Sondermeijer, Brigitte M., Boekholdt, S. Matthijs, Rana, Jamal S., Kastelein, John J.P., Wareham, Nicholas J., Khaw, Kay-Tee

Date : 07/05/2013
Ehjournal

The risk of tendon xanthomas in familial hypercholesterolaemia is influenced by variation in genes of the reverse cholesterol transport pathway and the low-density lipoprotein oxidation ...

European Heart Journal, Oosterveer, Daniëlla M., Versmissen, Jorie, Yazdanpanah, Mojgan, Defesche, Joep C., Kastelein, John J.P., Sijbrands, Eric J.G.

Date : 01/04/2010
Ehjournal

Mipomersen, an apolipoprotein B synthesis inhibitor, lowers low-density lipoprotein cholesterol in high-risk statin-intolerant patients: a randomized, double-blind, placebo-controlled trial Abstract ...

European Heart Journal, Visser, Maartje E., Wagener, Gilbert, Baker, Brenda F., Geary, Richard S., Donovan, Joanne M., Beuers, Ulrich H.W., Nederveen, Aart J., Verheij, Joanne, Trip, Mieke D., ...

Date : 01/05/2012 Item size : 315307 bytes
Ehjournal

Rather, they do so to better target therapy and improve the lives of their patients. [...]when considering the use of any biomarker for cardiovascular risk prediction in primary prevention, ...

European Heart Journal, Ridker, Paul M, Kastelein, John J.P., Genest, Jacques, Koenig, Wolfgang

Date : 01/05/2013 Item size : 180087 bytes
Ehjournal

Cardiovascular risk in relation to functionality of sequence variants in the gene coding for the low-density lipoprotein receptor: a study among 29 365 individuals tested for 64 specific low-density ...

European Heart Journal, Huijgen, Roeland, Kindt, Iris, Defesche, Joep C., Kastelein, John J.P.

Date : 01/09/2012 Item size : 218307 bytes
Ehjournal

Carriers of the CC genotype had a decreased risk of CVD (hazard ratio 0.67, 95% confidence interval 0.510.87; P = 0.003) relative to the other genotype groups. Introduction Atherosclerosis is a ...

European Heart Journal, Koeijvoets, Kristel C.M.C., Mooijaart, Simon P., Dallinga-Thie, Geesje M., Defesche, Joep C., Steyerberg, Ewout W., Westendorp, Rudi G.J., Kastelein, John J.P., van Hagen, P. ...

Date : 01/03/2009