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There is mounting evidence that thrombin acts as a powerful modulator of many processes like regulation of vascular tone, permeability, migration and proliferation of VSMC, recruitment of monocytes ...

Cardiovascular Research, Review, Julian Ilcheff Borissoff, Henri M.H. Spronk, Sylvia Heeneman, Hugo ten Cate

Date : 01/06/2009 Item size : 584450 bytes

Abstract Several pathologies of the cardiovascular system are associated with an augmented production of nitric oxide and/or superoxide-derived oxidants and/or alteration in the antioxidant ...

Cardiovascular Research, Review, Gonzalo Peluffo, Rafael Radi

Date : 15/07/2007 Item size : 511451 bytes

The role of reactive oxygen species and redox signalling in cardiovascular disease Reactive oxygen species (ROS) are generated during regulated physiological processes, and play a critical function ...

European Heart Journal, Clinical update, Keyvan Karimi Galougahi, Charalambos Antoniades, Stephen J. Nicholls, Keith M. Channon, Gemma A. Figtree

Date : 01/07/2015 Item size : 398285 bytes

Abstract Aims Recent studies have reported that the calcium-dependent protease calpain is involved in hyperglycaemia-induced endothelial dysfunction and that the Na+/H+ exchanger (NHE) is responsible ...

Cardiovascular Research, Original Article, Shuangxi Wang, Qisheng Peng, Junhua Zhang, Liying Liu

Date : 01/11/2008

In one clinical trial, 4444 patients were carefully studied and not only was simvastatin shown to be safe and effective in lowering circulating cholesterol, it also significantly improved survival in ...

Cardiovascular Research, Review, Allan M Lefer, Rosario Scalia, David J Lefer

Date : 01/02/2001

[11] (pages 130135) in this issue. 1 Introduction A widely accepted risk factor for the development of coronary artery disease is an elevated level of plasma cholesterol. Synthetic derivatives of ...

Cardiovascular Research, Editorial, Steven J Miller

Date : 01/10/2001

Methods and results In both cultured endothelial cells and blood vessels isolated from rat aorta, berberine concentration dependently enhanced phosphorylation of endothelial nitric oxide synthase ...

Cardiovascular Research, Original Article, Yiqun Wang, Yu Huang, Karen S.L. Lam, Yiming Li, Wing Tak Wong, Hongying Ye, Chi-Wai Lau, Paul M. Vanhoutte, Aimin Xu

Date : 01/06/2009

The clinical severity of vascular occlusive disease in DM-2 patients has, in part, been attributed to impaired collateral vessel development due to altered function of mature endothelial cells.2 ...

Cardiovascular Research, Review, Saher Hamed, Benjamin Brenner, Ariel Roguin

Date : 01/07/2011

Increased activity of arginase may reduce the availability of l-arginine for NO synthase, thus reducing NO production, increasing formation of reactive oxygen species, and leading ultimately to ...

Cardiovascular Research, TOPICAL REVIEW, John Pernow, Christian Jung

Date : 01/06/2013

Abstract An abnormal production of reactive oxygen species (ROS) and the subsequent decrease in vascular bioavailability of nitric oxide (NO) have long been proposed to be the common pathogenetic ...

European Heart Journal, Münzel, Thomas, Gori, Tommaso, Bruno, Rosa Maria, Taddei, Stefano

Date : 01/11/2010