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Ehjcardiovascrec

[...]the identification of key processes setting off a cascade of detrimental cellular changes, ultimately leading to the development of cardiac failure, is still subject of intense research. The ...

Cardiovascular Research, Review, Marc van Bilsen, Pascal J.H Smeets, Andries J Gilde, Ger J van der Vusse

Date : 01/02/2004 Item size : 428514 bytes
Ehjcardiovascrec

To this end, the molecular biology of calcineurin and its direct downstream transcriptional effector NFAT are discussed in the context of the genetic studies that established the existence of this ...

Cardiovascular Research, Review, Orlando F Bueno, Eva van Rooij, Jeffery D Molkentin, Pieter A Doevendans, Leon J De Windt

Date : 01/03/2002 Item size : 584271 bytes
Ehjcardiovascrec

Introduction Heart failure (HF) remains a major cause of death worldwide.1 (Refer to Table 1 for all list of acronyms in the manuscript.) It is frequently preceded by cardiac hypertrophy defined ...

Cardiovascular Research, Cardiac biology and remodelling, Mirna N. Chahine, Maxime Mioulane, Markus B. Sikkel, Peter O'Gara, Cristobal G. Dos Remedios, Grant N. Pierce, Alexander R. Lyon, Gábor ...

Date : 01/01/2015 Item size : 336287 bytes
Ehjcardiovascrec

To elucidate whether cardiac hypertrophy/insufficiency and reversal is associated with changes in the local responsiveness to NPs, we compared the mRNA expression of ANP, BNP and receptors and the ...

Cardiovascular Research, Research Article, Michaela Kuhn, Melanie Voß, Danuta Mitko, Jörg Stypmann, Christof Schmid, Naomasa Kawaguchi, Florian Grabellus, Hideo A. Baba

Date : 01/11/2004 Item size : 233424 bytes
Ehjcardiovascrec

[...]sustained hypertrophy has been associated with a significant increase in the risk of cardiovascular disease and mortality. [...]many researchers are trying to understand whether left ...

Cardiovascular Research, Review, Giulio Selvetella, Emilio Hirsch, Antonella Notte, Guido Tarone, Giuseppe Lembo

Date : 15/08/2004 Item size : 431911 bytes
Ehjcardiovascrec

Methods: In ten normal human hearts and ten hearts with idiopathic dilated cardiomyopathy (IDCM), the laminin-α2 and FN mRNA levels were quantified by slot-blot using total RNA and the protein ...

Cardiovascular Research, Original Article, Patricia Oliviéro, Catherine Chassagne, Nathalie Salichon, Alain Corbier, Gilles Hamon, Françoise Marotte, Danièle Charlemagne, Lydie Rappaport, ...

Date : 01/05/2000
Ehjcardiovascrec

Introduction AMP-activated protein kinase (AMPK) controls multiple catabolic and anabolic pathways that help maintain adequate cellular ATP levels in times of energetic and/or cellular stress.1,2 In ...

Cardiovascular Research, Original Article, Miranda M. Sung, Beshay N. Zordoky, Adam L. Bujak, James S.V. Lally, David Fung, Martin E. Young, Sandrine Horman, Edward J. Miller, Peter E. Light, Bruce ...

Date : 15/07/2015
Ehjcardiovascrec

Abstract Aims The Cav3.2 T-channel plays a pivotal role in inducing calcineurin/nuclear factor of activated T cell (NFAT) signalling during cardiac hypertrophy. Because calcineurin/NFAT signalling ...

Cardiovascular Research, Cardiac biology and remodelling, Shao-Chun Hsu, Ya-Ting Chang, Chien-Chang Chen

Date : 01/11/2013
Ehjcardiovascrec

Abstract Objective: The mitogen-activated kinase kinases (MEK)-extracellular signal-regulated kinases (ERK) signaling pathway is activated by agonists like catecholamines or endothelin-1 (ET-1) and ...

Cardiovascular Research, Original Article, Felix Münzel, Ulrike Mühlhäuser, Wolfram-Hubertus Zimmermann, Michael Didié, Karin Schneiderbanger, Pia Schubert, Sven Engmann, Thomas ...

Date : 01/12/2005
Ehjcardiovascrec

Myocardial hypertrophy is either a primary disease of the heart as found for genetic cardiomyopathies (hypertrophic or dilated), or an adaptative response secondary to, for instance, hemodynamic ...

Cardiovascular Research, Editorial, Stéphane Baudet

Date : 01/04/2000