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The ubiquitin-proteasome system (UPS) is an integral part of the protein metabolism machinery mediating post-transcriptional processing and degradation of the majority of intracellular ...

Cardiovascular Research, Review, Joerg Herrmann, Lilach O. Lerman, Amir Lerman

Date : 15/01/2010 Item size : 479470 bytes

[...]there is some evidence that the UPS itself modulates the activity of endothelial nitric oxide synthase, the key enzyme of vascular homeostasis, interacts with other vasoactive mediators involved ...

Cardiovascular Research, Review, Karl Stangl, Verena Stangl

Date : 15/01/2010 Item size : 509363 bytes

The ubiquitin-proteasome system (UPS) plays a pivotal role in the complex molecular network regulating the progression both between and within each cell-cycle phase. [...]we will focus our attention ...

Cardiovascular Research, Review, Pasquale Fasanaro, Maurizio C. Capogrossi, Fabio Martelli

Date : 15/01/2010 Item size : 501466 bytes

Occlusion of the left main coronary artery (one hour) followed by reperfusion (one hour) in the anesthetized rat caused severe cardiac necrosis, neutrophil infiltration, and increased plasma creatine ...

Cardiovascular Research, Original Article, Basilia Zingarelli, Salvatore Cuzzocrea, Zsuzsanna Zsengellér, Andrew L. Salzman, Csaba Szabó

Date : 01/11/1997 Item size : 197233 bytes

Attenuation of EC responsiveness to insulin results from T-cad-mediated chronic activation of the Akt/mTOR-dependent negative feedback loop of the insulin cascade and enhanced degradation of the ...

Cardiovascular Research, Original Article, Maria Philippova, Manjunath B. Joshi, Dennis Pfaff, Emmanouil Kyriakakis, Kseniya Maslova, Paul Erne, Thérèse J. Resink

Date : 01/03/2012 Item size : 312788 bytes

Introduction Atherosclerosis is a multifactorial disease that is characterized by chronic inflammation of the arterial wall.1 Both innate and adaptive immune responses play vital roles in the process ...

Cardiovascular Research, Vascular biology, Wencai Zhang, Tingting Tang, Daan Nie, Shuang Wen, Chenping Jia, Zhengfeng Zhu, Ni Xia, Shaofang Nie, Sufeng Zhou, Jiao Jiao, Wenyong Dong, Bingjie Lv, ...

Date : 01/06/2015 Item size : 403832 bytes

Abstract The development of efficient transgenic technologies in mice has allowed the study of the consequences of genetic alterations on cardiovascular (patho)physiology, although the development of ...

Cardiovascular Research, Review, Peter Carmeliet, Lieve Moons, Désiré Collen

Date : 01/07/1998 Item size : 965541 bytes

Methods: Shear stress and statin effects in combination with TNF-α were determined in human umbilical vein endothelial cells by quantitative measurements of the steady-state levels and stability ...

Cardiovascular Research, Original Article, Johannes V. van Thienen, Joost O. Fledderus, Rob J. Dekker, Jakub Rohlena, Gerben A. van IJzendoorn, Neeltje A. Kootstra, Hans Pannekoek, Anton J.G. ...

Date : 01/11/2006 Item size : 296044 bytes

A pivotal autocrine mechanism following endothelial cell activation is the release of angiopoietin-2 (Ang-2), which subsequently antagonizes the binding of Ang-1 to the Tie-2 receptor, thus ...

Cardiovascular Research, Original Article, Thomas Korff, Evelyn Ernst, Rainer Nobiling, Anja Feldner, Yvonne Reiss, Karl H. Plate, Ulrike Fiedler, Hellmut G. Augustin, Markus Hecker

Date : 01/06/2012 Item size : 319575 bytes

Methods: New Zealand White rabbits received MCP-1 or phosphate buffered saline (PBS) for a 1-week period, either directly or 3 weeks after femoral artery ligation (non-ischemic model). The ...

Cardiovascular Research, Original Article, Imo E. Hoefer, Niels van Royen, Ivo R. Buschmann, Jan J. Piek, Wolfgang Schaper

Date : 16/02/2001 Item size : 236168 bytes