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Abstract Atherosclerosis is considered to be a form of chronic inflammation governed by a complex network of inter- and intra-cellular signaling pathways. Introduction Atherosclerosis, an underlying ...

Cardiovascular Research, Review, Elizabeth J. Harvey, Dipak P. Ramji

Date : 01/07/2005 Item size : 433326 bytes

[...]NO production by endothelial cells was significantly reduced by ectopic expression of PMCA. Conclusion Our results show strong evidence for a novel functional interaction between endogenous ...

Cardiovascular Research, Original Article, MaryLouisa Holton, Tamer M.A. Mohamed, Delvac Oceandy, Weiguang Wang, Santiago Lamas, Michael Emerson, Ludwig Neyses, Angel L. Armesilla

Date : 01/08/2010 Item size : 257924 bytes

Levels of CRP are consistently associated with cardiovascular disease (CVD) and predict myocardial infarctions and stroke. Since CRP is present in the atherosclerotic lesion, it may actively ...

Cardiovascular Research, Review, Elaine Paffen, Moniek P.M. deMaat

Date : 01/07/2006 Item size : 473048 bytes

Abstract Macrophages play a key role in atherosclerotic plaque destabilization and rupture. [...]macrophages are phagocytic cells and thus have an important additional role in scavenging of modified ...

Cardiovascular Research, Review, Dorien M. Schrijvers, Guido R.Y. De Meyer, Arnold G. Herman, Wim Martinet

Date : 01/02/2007 Item size : 443225 bytes

Growing evidence suggests differences between these two cardiac endothelial cell types with regard to developmental, morphological and functional properties. KeywordsEndocardial endotheliumVascular ...

Cardiovascular Research, Review, Dirk L. Brutsaert, Paul Fransen, Luc J. Andries, Gilles W. De Keulenaer, Stanislas U. Sys

Date : 01/05/1998 Item size : 304791 bytes

Abstract The ability of the endothelium to produce nitric oxide, which induces generation of cyclic guanosine monophosphate (cGMP) that activates cGMP-dependent protein kinase (PKG-I), in vascular ...

Cardiovascular Research, TOPICAL REVIEW, Hassan Sellak, Chung-sik Choi, Nupur B. Dey, Thomas M. Lincoln

Date : 01/02/2013 Item size : 502834 bytes

Introduction Coronary artery disease is the leading cause of morbidity and mortality worldwide, and >7 million people die of the disease annually.1 In humans, irreversible damage to the myocardium, ...

Cardiovascular Research, REVIEWS: SPOTLIGHT ON REDUCING MYOCARDIAL ISCHAEMIA/REPERFUSION INJURY, Leo Timmers, Gerard Pasterkamp, Vince C. de Hoog, Fatih Arslan, Yolande Appelman, Dominique P.V. de ...

Date : 01/05/2012 Item size : 443263 bytes

Abstract The complex regulation of eNOS (endothelial nitric oxide synthase) in cardiovascular physiology occurs at multiple stages. eNOS mRNA levels are controlled both at the transcriptional and ...

Cardiovascular Research, Review, David M. Dudzinski, Thomas Michel

Date : 15/07/2007 Item size : 589333 bytes

In blood vessels, the CaR protein was first reported in perivascular nerves of rat mesenteric resistance arteries, and was proposed to modulate myogenic tone in the arteries. Furthermore, a recent ...

Cardiovascular Research, Review, Sanela Smajilovic, Jacob Tfelt-Hansen

Date : 01/08/2007 Item size : 430529 bytes

Rapamycin also impaired cell mobility, as assessed by a wound test, and promoted the formation of actin stress fibres, as determined with confocal microscopy. [...]the inhibitor prolonged ...

Cardiovascular Research, Original Article, Amelia Barilli, Rossana Visigalli, Roberto Sala, Gian C. Gazzola, Alessandro Parolari, Elena Tremoli, Sabrina Bonomini, Alexandra Simon, Ellen I. Closs, ...

Date : 01/06/2008 Item size : 295259 bytes