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The interactions of pulsatile blood flow with arterial geometries generate complex biomechanical forces on the vessel wall with spatial and temporal variations. [...]arteries are exposed to ...

European Heart Journal, Basic science for the clinician, Brenda R. Kwak, Magnus Bäck, Marie-Luce Bochaton-Piallat, Giuseppina Caligiuri, Mat J.A.P. Daemen, Peter F. Davies, Imo E. Hoefer, Paul ...

Date : 14/11/2014 Item size : 676164 bytes

MicroRNAs (miRNAs) are an emerging class of highly conserved, non-coding small RNAs that regulate gene expression on the post-transcriptional level by inhibiting the translation of protein from mRNA ...

Cardiovascular Research, REVIEWS: FOCUS ON MICRO RNA, Carmen Urbich, Angelika Kuehbacher, Stefanie Dimmeler

Date : 01/09/2008 Item size : 384605 bytes

Abstract A fundamental feature of any immune response is the movement of leucocytes from one site in the body to another to provide effector functions. [...]elucidating the molecular mechanisms ...

Cardiovascular Research, SPOTLIGHT REVIEWS, Connie H.Y. Wong, Bryan Heit, Paul Kubes

Date : 01/05/2010 Item size : 487398 bytes

Methods and results miR-214 is expressed in all major vascular cell types, and modulation of miR-214 levels in endothelial cells significantly affected tubular sprouting. Quaking knockdown reduced ...

Cardiovascular Research, ORIGINAL ARTICLES: FOCUS ON MICRORNA IN CARDIOVASCULAR BIOLOGY AND DISEASE, Alain van Mil, Sebastian Grundmann, Marie-José Goumans, Zhiyong Lei, Martinus I. Oerlemans, ...

Date : 15/03/2012 Item size : 283244 bytes

[...]among a large array of novel therapeutic agents with anti-angiogenic activity tested in the clinical setting in the past decade, the humanized version of a murine anti-vascular endothelial ...

Cardiovascular Research, Editorial, Michele Maio, Maresa Altomonte, Ester Fonsatti

Date : 01/03/2006 Item size : 162203 bytes

Smoking is also a major independent risk factor for atherosclerotic vascular diseases, including coronary artery disease and cerebrovascular attack. [...]the mechanisms responsible for the ...

Cardiovascular Research, Editorial, Toshihiro Ichiki

Date : 01/06/2011 Item size : 160813 bytes

Methods: Granulocyte-monocyte colony stimulating factor mobilized human CD34+ cells were isolated and grown in culture in the presence of vascular endothelial growth factor (50 ng/ml) and basic ...

Cardiovascular Research, Original Article, Danièle Nakul-Aquaronne, Jacques Bayle, Christian Frelin

Date : 01/03/2003 Item size : 208316 bytes

An interesting report by Boengler and colleagues, appearing in this issue of Cardiovascular Research [2], has helped in this regard by identifying links between biomechanical stress and expression of ...

Cardiovascular Research, Editorial, Arthur R Strauch

Date : 01/09/2003 Item size : 150254 bytes

Introduction The epicardium, a specialized epithelial cell layer that covers the heart, is essential to cardiac development, structure, and function.1,2 During development, a subset of epicardial ...

Cardiovascular Research, Original Article, Krithika S. Rao, Alexander Aronshtam, Keara L. McElory-Yaggy, Benjamin Bakondi, Peter VanBuren, Burton E. Sobel, Jeffrey L. Spees

Date : 15/07/2015 Item size : 330450 bytes

HIF-1 consists of O2-regulated HIF-1α and constitutively expressed HIF-1β subunits.1 HIF-2α is a HIF-1α paralogue that is also involved in vascular responses to ischaemia.2,3 In humans, ...

Cardiovascular Research, SPOTLIGHT REVIEWS, Sergio Rey, Gregg L. Semenza

Date : 01/05/2010 Item size : 454352 bytes