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The ubiquitin-proteasome system (UPS) is an integral part of the protein metabolism machinery mediating post-transcriptional processing and degradation of the majority of intracellular ...

Cardiovascular Research, Review, Joerg Herrmann, Lilach O. Lerman, Amir Lerman

Date : 15/01/2010 Item size : 479470 bytes

The ubiquitin-proteasome system (UPS) plays a pivotal role in the complex molecular network regulating the progression both between and within each cell-cycle phase. [...]we will focus our attention ...

Cardiovascular Research, Review, Pasquale Fasanaro, Maurizio C. Capogrossi, Fabio Martelli

Date : 15/01/2010 Item size : 501466 bytes

Occlusion of the left main coronary artery (one hour) followed by reperfusion (one hour) in the anesthetized rat caused severe cardiac necrosis, neutrophil infiltration, and increased plasma creatine ...

Cardiovascular Research, Original Article, Basilia Zingarelli, Salvatore Cuzzocrea, Zsuzsanna Zsengellér, Andrew L. Salzman, Csaba Szabó

Date : 01/11/1997 Item size : 197233 bytes

Abstract Aims Pulmonary arterial hypertension (PAH) is a progressive lung disease characterized by pulmonary vasoconstriction and vascular remodelling, leading to increased pulmonary vascular ...

Cardiovascular Research, Original Article, Philip M. Bauer, Eileen M. Bauer, Natasha M. Rogers, Mingyi Yao, Monica Feijoo-Cuaresma, Joseph M. Pilewski, Hunter C. Champion, Brian S. Zuckerbraun, Maria ...

Date : 15/03/2012 Item size : 350153 bytes

[...]oxidative stress and mtDNA damage are good therapeutic targets. Consistent with alterations in mtDNA, the decrease in mitochondrial function was also prevented. [...]the activation of Prx-3 or ...

Cardiovascular Research, Review, Hiroyuki Tsutsui, Shintaro Kinugawa, Shouji Matsushima

Date : 15/02/2009 Item size : 443610 bytes

Stroke is the second leading cause of disability after ischaemic heart disease.1,2 The World Health Organization estimates that the number of stroke events in Europe is projected to rise from 1.1 ...

European Heart Journal, Editorial, Massimo Volpe, Francesco Paneni

Date : 01/07/2015 Item size : 195188 bytes

Dihydroethidium staining and nitrotyrosine staining were also elevated in endothelial cells of ritonavir-treated vessels, indicating increased superoxide production and increased oxidative stress, ...

Cardiovascular Research, Original Article, Brian S Conklin, Weiping Fu, Peter H Lin, Alan B Lumsden, Qizhi Yao, Changyi Chen

Date : 01/07/2004 Item size : 264779 bytes

[...]reducing heart rate could protect the endothelium and slow the onset of atherosclerosis. Context Resting heart rate is a basic and simple physiological parameter of the physical examination ...

Cardiovascular Research, Review, Eric Thorin, Nathalie Thorin-Trescases

Date : 01/10/2009 Item size : 455435 bytes

Functionally, this mechanism stimulates collagen expression thereby implicating the adventitia as a potential contributor to the vascular pathophysiology associated with oxidative stress and vascular ...

Cardiovascular Research, Original Article in the Review Focus Series on Adventitial Control of Vascular Function and Growth, Sheng Jun An, Ryan Boyd, Min Zhu, Alexander Chapman, David R. Pimentel, ...

Date : 01/09/2007 Item size : 315402 bytes

Introduction Systemic hypertension, hypercholesterolaemia, and diabetes are associated with endothelial dysfunction that promotes inflammation, oxidation of lipoproteins, smooth muscle proliferation, ...

Cardiovascular Research, Review, Kwang Kon Koh, Pyung Chun Oh, Michael J. Quon

Date : 01/03/2009 Item size : 535454 bytes