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Methods and results To study the effect of miR-106b25 deletion on neovascularization, we used a miR-106b25 knockout (KO) mouse model. The miR-106b25 cluster was also shown here to be an essential ...

European Heart Journal, BASIC SCIENCES, Jonathan Semo, Rinat Sharir, Arnon Afek, Camila Avivi, Iris Barshack, Sofia Maysel-Auslender, Yakov Krelin, David Kain, Michal Entin-Meer, Gad Keren, Jacob ...

Date : 01/12/2014 Item size : 287858 bytes

The interactions of pulsatile blood flow with arterial geometries generate complex biomechanical forces on the vessel wall with spatial and temporal variations. [...]arteries are exposed to ...

European Heart Journal, Basic science for the clinician, Brenda R. Kwak, Magnus Bäck, Marie-Luce Bochaton-Piallat, Giuseppina Caligiuri, Mat J.A.P. Daemen, Peter F. Davies, Imo E. Hoefer, Paul ...

Date : 14/11/2014 Item size : 676164 bytes

Obesity and excessive weight put a strain on the entire circulatory system.1 Obese individuals are also more likely to have high cholesterol, high blood pressure, and diabetesall of which may further ...

European Heart Journal, Editorial, Francesco Paneni, Sarah Costantino, Francesco Cosentino

Date : 15/11/2014 Item size : 186028 bytes

Stroke is the second leading cause of disability after ischaemic heart disease.1,2 The World Health Organization estimates that the number of stroke events in Europe is projected to rise from 1.1 ...

European Heart Journal, Editorial, Massimo Volpe, Francesco Paneni

Date : 01/07/2015 Item size : 195188 bytes

The role of reactive oxygen species and redox signalling in cardiovascular disease Reactive oxygen species (ROS) are generated during regulated physiological processes, and play a critical function ...

European Heart Journal, Clinical update, Keyvan Karimi Galougahi, Charalambos Antoniades, Stephen J. Nicholls, Keith M. Channon, Gemma A. Figtree

Date : 01/07/2015 Item size : 398285 bytes

The cardiac endothelium in cardiovascular homeostasis In the pathophysiology of HF, a pivotal role has been attributed to generalized endothelial dysfunction, in particular in the cardiac, pulmonary, ...

European Heart Journal, Clinical update, Shir Lynn Lim, Carolyn S.P. Lam, Vincent F.M. Segers, Dirk L. Brutsaert, Gilles W. De Keulenaer

Date : 14/08/2015 Item size : 707313 bytes

Accumulation of reactive oxygen species (ROS) may interfere with vascular repair, but the underlying mechanisms remain unknown. Endothelial progenitor cellsAgeingRegenerative medicineCardiovascular ...

European Heart Journal, BRIEF COMMUNICATION, Francesco Paneni, Sarah Costantino, Nicolle Kränkel, Francesco Cosentino, Thomas F. Lüscher

Date : 07/06/2016 Item size : 221671 bytes

Activated upon caloric restriction and exercise, they control critical cellular processes in the nucleus, cytoplasm, and mitochondria to maintain metabolic homeostasis, reduce cellular damage and ...

European Heart Journal, Review, Stephan Winnik, Johan Auwerx, David A. Sinclair, Christian M. Matter

Date : 21/12/2015 Item size : 553794 bytes

Adipose tissue has been recognized as a source of cytokines that contributes to chronic inflammation in patients with metabolic syndrome and diabetes.1,2 Furthermore, perivascular epicardial adipose ...

European Heart Journal, ISSUE @ A GLANCE, Thomas F. Lüscher

Date : 01/04/2015 Item size : 211154 bytes

[...]cells that adhere onto tissue culture plastic in serum-containing growth medium and have adipogenic, osteogenic, and chondrogenic differentiation potential in culture were termed mesenchymal ...

European Heart Journal, CURRENT OPINION, Rosalinda Madonna, Linda W. Van Laake, Sean M. Davidson, Felix B. Engel, Derek J. Hausenloy, Sandrine Lecour, Jonathan Leor, Cinzia Perrino, Rainer Schulz, ...

Date : 14/06/2016