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Chamber specification is tightly co-ordinated by temporal and spatial expression of cardiac transcription factors such as T-box transcription factor 5 (Tbx5), GATA-binding protein 4 (Gata4), Myocyte ...

Cardiovascular Research, TOPICAL REVIEW, Prabhu Mathiyalagan, Samuel T. Keating, Xiao-Jun Du, Assam El-Osta

Date : 01/07/2014 Item size : 624022 bytes

Introduction A clear association between adverse intrauterine environment and increased risk of heart disease later in life has been demonstrated in recent epidemiological and animal studies.14 A ...

Cardiovascular Research, Original Article, Andrew J. Patterson, Daliao Xiao, Fuxia Xiong, Brandon Dixon, Lubo Zhang

Date : 01/02/2012 Item size : 322301 bytes

Abstract Objective: To summarize the structure, function, and regulation of matrix metalloproteinases (MMPs) and to review the literature to date on their potential role in the pathogenesis of acute ...

Cardiovascular Research, Review, Charles B Jones, David C Sane, David M Herrington

Date : 01/10/2003 Item size : 533289 bytes

Abstract Objective: Chronic β-adrenergic stimulation of the cAMP-dependent signalling pathway is implicated in functionally relevant expressional changes in congestive heart ...

Cardiovascular Research, Original Article, Frank U Müller, Peter Bokník, Jörg Knapp, Bettina Linck, Hartmut Lüss, Joachim Neumann, Wilhelm Schmitz

Date : 01/10/2001 Item size : 279952 bytes

The detailed understanding of the promoter regions essential for gene transcription and the different transcription factors, which are involved in promoter activation, is one of the scientific ...

Cardiovascular Research, Editorial, Markus Flesch

Date : 01/04/2001 Item size : 254094 bytes

Diminished NO levels have been, in fact, associated with atherosclerosis, cardiac infarction, and diabetes, to cite some the most common occurrences.4,5 In mice knock-out for NO synthases, several ...

Cardiovascular Research, REVIEWS: FOCUS ON EPIGENETICS AND THE HISTONE CODE IN VASCULAR BIOLOGY, Barbara Illi, Claudia Colussi, Jessica Rosati, Francesco Spallotta, Simona Nanni, Antonella Farsetti, ...

Date : 01/06/2011 Item size : 585803 bytes

Systemic crude E. coli LPS administration decreased mtDNA copy number and mtDNA gene transcription in rat heart caused by oxidant deletion of mtDNA. The fall in copy number was reflected in ...

Cardiovascular Research, Research Article, Hagir B. Suliman, Karen E. Welty-Wolf, MarthaSue Carraway, Lynn Tatro, Claude A. Piantadosi

Date : 01/11/2004 Item size : 316915 bytes

Of special clinical importance are β-adrenoceptors, which mediate the effects of the sympathetic nervous system. In turn, PKA increases the phosphorylation state of target proteins in the cardiac ...

Cardiovascular Research, Editorial, Joachim Neumann

Date : 01/07/2006 Item size : 151590 bytes

KeywordsAldosteroneMineralo-receptorFibrosisHeartHypertensionTime for primary review 29 days. 1 Introduction Aldosterone (Aldo) plays an essential role in regulation of body sodium and potassium ...

Cardiovascular Research, Review, Claude Delcayre, Jean-Sébastien Silvestre

Date : 01/07/1999 Item size : 245502 bytes

Abstract In response to pathologic stresses such as hypertension or myocardial infarction, the heart undergoes a remodeling process that is characterized by myocyte hypertrophy, myocyte death and ...

Cardiovascular Research, Review in Review Focus Series on Calmodulin and Ca2+/Calmodulin Kinases in the Heart, Timothy A. McKinsey

Date : 01/03/2007 Item size : 546001 bytes