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Ehjcardiovascrec

Methods For analysis of transcriptional targeting, recombinant AAV vectors were generated harboring a luciferase reporter gene under control of the cytomegalovirus (CMV) promoter or the 1.5-kb ...

Cardiovascular Research, Original Article, Oliver J. Müller, Barbara Leuchs, Sven T. Pleger, Dirk Grimm, Wolfgang-M. Franz, Hugo A. Katus, Jürgen A. Kleinschmidt

Date : 01/04/2006 Item size : 295855 bytes
Ehjcardiovascrec

Abstract Objective: The introduction of recombinant genes into endothelial cells provides a method to study specific gene products and their effect on cell function. [...]endothelial cells can be ...

Cardiovascular Research, Original Article, Felix C Tanner, Dianne P Carr, Gary J Nabel, Elizabeth G Nabel

Date : 01/09/1997 Item size : 281054 bytes
Ehjcardiovascrec

Abstract With evolving knowledge in molecular and cellular cardiology, cardiac gene therapy has already been investigated in clinical studies. Introduction In the last decades, potential therapeutic ...

Cardiovascular Research, Review, Oliver J. Müller, Hugo A. Katus, Raffi Bekeredjian

Date : 01/02/2007
Ehjcardiovascrec

Estrogen receptor-α gene transfer into bovine aortic endothelial cells induces eNOS gene expression and inhibits cell migration Abstract Objectives: It has been suggested that estrogen may ...

Cardiovascular Research, Original Article, Enqing Tan, Milind V Gurjar, Ram V Sharma, Ramesh C Bhalla

Date : 15/08/1999
Ehjcardiovascrec

Angiogenesis by gene transfer provides an attractive alternative, with the advantage that the protein may continue to be secreted for a longer period of time and that the gene may be targeted to ...

Cardiovascular Research, Review, Basil S Lewis, Moshe Y Flugelman, Anat Weisz, Iris Keren-Tal, Wolfgang Schaper

Date : 01/09/1997
Ehjcardiovascrec

Methods and results Based on a tetracycline-inducible transactivator, we designed an AAV vector system allowing the pharmacological regulation of VEGF production in vivo and tested its efficacy in ...

Cardiovascular Research, Original Article, Sabrina Tafuro, Eduard Ayuso, Serena Zacchigna, Lorena Zentilin, Silvia Moimas, Franca Dore, Mauro Giacca

Date : 01/09/2009
Ehjcardiovascrec

Abstract Objective: We examined the functional consequences of expressing adult rabbit fast skeletal sarcoplasmic reticulum (SR) Ca2+-ATPase (SERCA1a) in isolated adult rat ventricular ...

Cardiovascular Research, Original Article, Nathalie Chossat, Frank Griscelli, Philippe Jourdon, Damien Logeart, Thierry Ragot, Michèle Heimburger, Michel Perricaudet, Anne-Marie Lompré, ...

Date : 01/02/2001
Ehjcardiovascrec

Increasingly, experimental evidence suggests that the role of SR Ca2+ cycling extends beyond the traditional biophysical control of cardiomyocyte contraction and relaxation, with SR Ca2+ cycling ...

Cardiovascular Research, EDITORIALS: SPOTLIGHT ON T-TUBULES AND RYANODINE RECEPTOR MICRODOMAIN SIGNALLING IN CARDIAC HYPERTROPHY AND FAILURE, William E. Louch, Alexander R. Lyon

Date : 01/05/2013
Ehjcardiovascrec

Which is the appropriate delivery system to introduce the vector into an adult organism? A beneficial therapeutic effect of a gene when expressed in the target cell type may turn into the opposite ...

Cardiovascular Research, Editorial, Axel Gödecke

Date : 01/04/2006
Ehjcardiovascrec

Secondary skin grafts of donor type and of third party were promptly rejected in the recipients that accepted cardiac allografts. Introduction Cardiac transplantation has evolved into a standard ...

Cardiovascular Research, Original Article, Atsushi Izawa, Kenji Sano, Megumi Takehara, Manabu Inobe, Jun-ichi Suzuki, Hiroshi Imamura, Masafumi Takahashi, Uichi Ikeda, Mitsuaki Isobe, Toshimitsu Uede

Date : 01/01/2006