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Introduction A clear association between adverse intrauterine environment and increased risk of heart disease later in life has been demonstrated in recent epidemiological and animal studies.14 A ...

Cardiovascular Research, Original Article, Andrew J. Patterson, Daliao Xiao, Fuxia Xiong, Brandon Dixon, Lubo Zhang

Date : 01/02/2012 Item size : 322301 bytes

Systemic crude E. coli LPS administration decreased mtDNA copy number and mtDNA gene transcription in rat heart caused by oxidant deletion of mtDNA. The fall in copy number was reflected in ...

Cardiovascular Research, Research Article, Hagir B. Suliman, Karen E. Welty-Wolf, MarthaSue Carraway, Lynn Tatro, Claude A. Piantadosi

Date : 01/11/2004 Item size : 316915 bytes

Reactive oxygen species (ROS) such as superoxide and H2O2 function as signaling molecules in many aspects of growth factor-mediated responses including angiogenesis. Vascular endothelial growth ...

Cardiovascular Research, Review, Masuko Ushio-Fukai

Date : 15/07/2006 Item size : 528604 bytes

Abstract The endothelium plays a key role in the maintenance of vascular homeostasis, and increased oxidative stress in vascular disease leads to reduced nitric oxide bioavailability and impaired ...

Cardiovascular Research, Review, Giovanni E. Mann, David J. Rowlands, Francois Y.L. Li, Patricia de Winter, Richard C.M. Siow

Date : 15/07/2007 Item size : 768335 bytes

Nonetheless, cardiac remodelling seems to develop in response to increased haemodynamic overload, increased workload, increased ventricular wall tension as well as elevated levels of different ...

Cardiovascular Research, Review, Naranjan S. Dhalla, Harjot K. Saini-Chohan, Delfin Rodriguez-Leyva, Vijayan Elimban, Melissa R. Dent, Paramjit S. Tappia

Date : 15/02/2009 Item size : 566412 bytes

Abstract Reactive oxygen species (ROS) are acknowledged generally to be multi-faceted regulators of cellular functions that trigger various pathological states when present chronically or transiently ...

Cardiovascular Research, Review, Leni Moldovan, Karthikeyan Mythreye, Pascal J. Goldschmidt-Clermont, Lisa L. Satterwhite

Date : 15/07/2006 Item size : 626534 bytes

Rationale Oxidative stress plays a significant role in the development of heart failure. H2O2 (a physiologically-relevant form of oxidative stress) induces substantial changes in gene expression in ...

Heart, BSCR Autumn Meeting 2014 Abstracts, SJ Leonard, PH Sugden, A Clerk

Date : 01/12/2014

Abstract Markers of increased oxidative stress are known to be elevated following acute myocardial infarction and in the context of chronic left ventricular hypertrophy or heart failure, and their ...

Cardiovascular Research, Review, Colin E. Murdoch, Min Zhang, Alison C. Cave, Ajay M. Shah

Date : 15/07/2006

Two principal isozymes of heme oxygenase have been identified, a constitutive isoform HO-2 (Mr34000) and an inducible isoform HO-1 (Mr32000), which is expressed at a low basal level in vascular ...

Cardiovascular Research, Review, Richard C.M. Siow, Hideyo Sato, Giovanni E. Mann

Date : 01/02/1999

In order to gain a better understanding of general aspects of aging and to identify aging biomarkers, we are currently using DNA microarray analysis to study caloric restriction (CR) as a model ...

Cardiovascular Research, Review, Sang-Kyu Park, Tomas A. Prolla

Date : 01/05/2005