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Role of Ca2+/calmodulin-dependent protein kinase II in cardiac hypertrophy and heart failure Abstract Ca2+/calmodulin-dependent protein kinase II (CaMKII), a critical transducer of Ca2+ signaling, ...

Cardiovascular Research, Review, Tong Zhang, Joan Heller Brown

Date : 15/08/2004 Item size : 465186 bytes

In this review, we summarize the evidence for and against the PKC hypothesis of preconditioning, discuss the important technical limitations currently hampering PKC research, and suggest new ...

Cardiovascular Research, Review, Boris Z. Simkhovich, Karin Przyklenk, Robert A. Kloner

Date : 01/10/1998 Item size : 497847 bytes

Abstract Objectives: The molecular mechanisms underlying the relationship between elevated plasma concentrations of triglyceride-rich lipoproteins and coronary artery disease remain uncertain. In ...

Cardiovascular Research, Original Article, G.D. Norata, A. Pirillo, E. Callegari, A. Hamsten, A.L. Catapano, P. Eriksson

Date : 01/07/2003 Item size : 320426 bytes

Abstract Objective: Chronic β-adrenergic stimulation of the cAMP-dependent signalling pathway is implicated in functionally relevant expressional changes in congestive heart ...

Cardiovascular Research, Original Article, Frank U Müller, Peter Bokník, Jörg Knapp, Bettina Linck, Hartmut Lüss, Joachim Neumann, Wilhelm Schmitz

Date : 01/10/2001 Item size : 279952 bytes

Abstract Fibroblast growth factor 2 (FGF-2), a multifunctional polypeptide that affects cell growth and differentiation and becomes upregulated by stress, is expressed as AUG-initiated 18 kDa FGF-2 ...

Cardiovascular Research, Review, Elissavet Kardami, Zhi-Sheng Jiang, Sarah K Jimenez, Cheryl J Hirst, Farah Sheikh, Peter Zahradka, Peter A Cattini

Date : 15/08/2004 Item size : 376385 bytes

Abstract Objective: The cardiac ankyrin repeat protein (CARP), a nuclear transcription co-factor that negatively regulates cardiac gene expression, is increased in human heart failure and in animal ...

Cardiovascular Research, Original Article, Oliver Zolk, Michael Marx, Elmar Jäckel, Ali El-Armouche, Thomas Eschenhagen

Date : 01/09/2003 Item size : 258892 bytes

KeywordsAldosteroneMineralo-receptorFibrosisHeartHypertensionTime for primary review 29 days. 1 Introduction Aldosterone (Aldo) plays an essential role in regulation of body sodium and potassium ...

Cardiovascular Research, Review, Claude Delcayre, Jean-Sébastien Silvestre

Date : 01/07/1999 Item size : 245502 bytes

Abstract In response to pathologic stresses such as hypertension or myocardial infarction, the heart undergoes a remodeling process that is characterized by myocyte hypertrophy, myocyte death and ...

Cardiovascular Research, Review in Review Focus Series on Calmodulin and Ca2+/Calmodulin Kinases in the Heart, Timothy A. McKinsey

Date : 01/03/2007 Item size : 546001 bytes

TAC-induced elevation of Cn expression and activity in WT was absent in CnAβ hearts, and the latter accordingly developed less cardiac hypertrophy (50 vs. 100% increase in heart weight/tibia ...

Cardiovascular Research, Original Article, Steven Hsu, Takahiro Nagayama, Norimichi Koitabashi, Manling Zhang, Liye Zhou, Djahida Bedja, Kathleen L. Gabrielson, Jeffery D. Molkentin, David A. Kass, ...

Date : 01/02/2009

To test this hypothesis, the effect of mechanical load on the activation of extracellular signal-regulated kinase (ERK) 1/2, p46/54JNK, and p38MAPK was examined in rat cardiac ...

Cardiovascular Research, Original Article, Jenny Papakrivopoulou, Gisela E Lindahl, Jill E Bishop, Geoffrey J Laurent

Date : 01/03/2004