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KeywordsDilated cardiomyopathyHeart failureCardiac performanceAcromegalyTime for primary review 31 days. 1 Introduction Growth hormone (GH) controls linear growth and a variety of other functions, ...

Cardiovascular Research, Review, Luigi Saccà

Date : 01/10/1997 Item size : 322191 bytes

Abstract A fundamental structural event in the progression of heart failure due to dilated cardiomyopathy is left ventricular (LV) myocardial remodeling. Using a broad-spectrum pharmacological MMP ...

Cardiovascular Research, Review, Francis G Spinale, Mytsi L Coker, Brian R Bond, James L Zellner

Date : 01/05/2000 Item size : 402448 bytes

[...]overshooting activation is likely to have negative long-term effects [2]. [...]it is worth to investigate whether disturbances of the myocardial Ca2+ homeostasis, which occur in experimental ...

Cardiovascular Research, Original Article, Hans Reinecke, Roland Vetter, Helmut Drexler

Date : 01/11/1997 Item size : 245260 bytes

An ideal animal model for any cardiovascular disease in humans should have five characteristics: (i) mimic the human disease, (ii) allow studies in chronic, stable disease, (iii) produce symptoms ...

Cardiovascular Research, Review, Sheila A Doggrell, Lindsay Brown

Date : 01/07/1998 Item size : 693819 bytes

The widely used model is the spontaneous hypertensive rat (SHR) with a polygenic determination of hypertension has been a useful tool for the study of pathophysiological alterations in hypertensive ...

Cardiovascular Research, Original Article, Oliver Zolk, Markus Flesch, Georg Nickenig, Petra Schnabel, Michael Böhm

Date : 01/07/1998 Item size : 587738 bytes

[...]there is evidence to suggest that another factor plays an important role, since there is a marked discrepancy between the haemodynamic manifestations of acute pulmonary embolism and the degree ...

Cardiovascular Research, Review, Yvo M. Smulders

Date : 01/10/2000 Item size : 489723 bytes

Chamber specification is tightly co-ordinated by temporal and spatial expression of cardiac transcription factors such as T-box transcription factor 5 (Tbx5), GATA-binding protein 4 (Gata4), Myocyte ...

Cardiovascular Research, TOPICAL REVIEW, Prabhu Mathiyalagan, Samuel T. Keating, Xiao-Jun Du, Assam El-Osta

Date : 01/07/2014 Item size : 624022 bytes

Abstract Activation of the immune system and derangement of cardiorespiratory neural control are established elements of the complex pathophysiology of chronic heart failure (CHF). Damaged heart ...

Cardiovascular Research, Review, Ewa A. Jankowska, Piotr Ponikowski, Massimo F. Piepoli, Waldemar Banasiak, Stefan D. Anker, Philip A. Poole-Wilson

Date : 01/06/2006 Item size : 704736 bytes

[...]it has become clear that the UPS is involved in most aspects of eukaryotic biology, such as intracellular signaling, transcriptional control, or regulation of cell death. Recent studies ...

Cardiovascular Research, Review, Oliver Zolk, Carolus Schenke, Antonio Sarikas

Date : 01/06/2006 Item size : 424616 bytes

Three factors combine to the enhanced propensity for the occurrence of delayed afterdepolarizations: (1) increased activity of the Na/Ca exchanger, (2) a reduced inward rectifier, (3) residual ...

Cardiovascular Research, Review, Michiel J Janse

Date : 01/02/2004 Item size : 449802 bytes