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KeywordsDilated cardiomyopathyHeart failureCardiac performanceAcromegalyTime for primary review 31 days. 1 Introduction Growth hormone (GH) controls linear growth and a variety of other functions, ...

Cardiovascular Research, Review, Luigi Saccà

Date : 01/10/1997 Item size : 322191 bytes

[...]overshooting activation is likely to have negative long-term effects [2]. [...]it is worth to investigate whether disturbances of the myocardial Ca2+ homeostasis, which occur in experimental ...

Cardiovascular Research, Original Article, Hans Reinecke, Roland Vetter, Helmut Drexler

Date : 01/11/1997 Item size : 245260 bytes

An ideal animal model for any cardiovascular disease in humans should have five characteristics: (i) mimic the human disease, (ii) allow studies in chronic, stable disease, (iii) produce symptoms ...

Cardiovascular Research, Review, Sheila A Doggrell, Lindsay Brown

Date : 01/07/1998 Item size : 693819 bytes

The widely used model is the spontaneous hypertensive rat (SHR) with a polygenic determination of hypertension has been a useful tool for the study of pathophysiological alterations in hypertensive ...

Cardiovascular Research, Original Article, Oliver Zolk, Markus Flesch, Georg Nickenig, Petra Schnabel, Michael Böhm

Date : 01/07/1998 Item size : 587738 bytes

Chamber specification is tightly co-ordinated by temporal and spatial expression of cardiac transcription factors such as T-box transcription factor 5 (Tbx5), GATA-binding protein 4 (Gata4), Myocyte ...

Cardiovascular Research, TOPICAL REVIEW, Prabhu Mathiyalagan, Samuel T. Keating, Xiao-Jun Du, Assam El-Osta

Date : 01/07/2014 Item size : 624022 bytes

[...]the identification of key processes setting off a cascade of detrimental cellular changes, ultimately leading to the development of cardiac failure, is still subject of intense research. The ...

Cardiovascular Research, Review, Marc van Bilsen, Pascal J.H Smeets, Andries J Gilde, Ger J van der Vusse

Date : 01/02/2004 Item size : 428514 bytes

Introduction Fibroblast growth factor 21 (Fgf21) is a secreted protein involved in the control of glucose homeostasis, insulin sensitivity, and ketogenesis.1,2 The liver is considered the main site ...

Cardiovascular Research, Cardiac biology and remodelling, Anna Planavila, Ibon Redondo-Angulo, Francesc Ribas, Gloria Garrabou, Jordi Casademont, Marta Giralt, Francesc Villarroya

Date : 01/04/2015 Item size : 320192 bytes

Role of Ca2+/calmodulin-dependent protein kinase II in cardiac hypertrophy and heart failure Abstract Ca2+/calmodulin-dependent protein kinase II (CaMKII), a critical transducer of Ca2+ signaling, ...

Cardiovascular Research, Review, Tong Zhang, Joan Heller Brown

Date : 15/08/2004 Item size : 465186 bytes

Pharmacological studies have established that a blockade of the RAS at the level of the angiotensin-converting enzyme (ACE) or the AT1-receptor ameliorates the remodeling process of the heart and ...

Cardiovascular Research, Review, Kai C Wollert, Helmut Drexler

Date : 01/09/1999 Item size : 591071 bytes

Abstract Aims High mobility group box 1 (HMGB1) is an abundant and ubiquitous nuclear DNA-binding protein that has multiple functions dependent on its cellular location. Conclusion These results ...

Cardiovascular Research, Cardiac biology and remodelling, Akira Funayama, Tetsuro Shishido, Shunsuke Netsu, Taro Narumi, Shinpei Kadowaki, Hiroki Takahashi, Takuya Miyamoto, Tetsu Watanabe, ...

Date : 01/09/2013 Item size : 301103 bytes