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In the heart, NO is produced by neuronal and endothelial NO synthase (nNOS and eNOS), which are constitutively expressed in cardiomyocytes and playing specific roles on the modulation of contractile ...

Cardiovascular Research, Original Article, Qian-Chen Yong, Li-Fang Hu, Suhua Wang, Dejian Huang, Jin-Song Bian

Date : 01/12/2010 Item size : 331095 bytes

There is mounting evidence that thrombin acts as a powerful modulator of many processes like regulation of vascular tone, permeability, migration and proliferation of VSMC, recruitment of monocytes ...

Cardiovascular Research, Review, Julian Ilcheff Borissoff, Henri M.H. Spronk, Sylvia Heeneman, Hugo ten Cate

Date : 01/06/2009 Item size : 584450 bytes

A key molecule for this fast response, which links alveolar ventilation (and thus the degree of regional oxygenation) to local lung perfusion is nitric oxide [5]: It has been conclusively shown that ...

Cardiovascular Research, Review in Review Focus Series on Hypoxia and the Pulmonary Circulation, Hossein A. Ghofrani, Robert Voswinckel, Frank Reichenberger, Norbert Weissmann, Ralph T. Schermuly, ...

Date : 01/10/2006 Item size : 485732 bytes

Abstract Aims Pulmonary arterial hypertension (PAH) is a progressive lung disease characterized by pulmonary vasoconstriction and vascular remodelling, leading to increased pulmonary vascular ...

Cardiovascular Research, Original Article, Philip M. Bauer, Eileen M. Bauer, Natasha M. Rogers, Mingyi Yao, Monica Feijoo-Cuaresma, Joseph M. Pilewski, Hunter C. Champion, Brian S. Zuckerbraun, Maria ...

Date : 15/03/2012 Item size : 350153 bytes

The mechanisms proposed to contribute include oxygen free radical formation, calcium overload, neutrophil-mediated myocardial and endothelial injury, progressive decline in microvascular flow to the ...

Cardiovascular Research, Review, Qing-Dong Wang, John Pernow, Per-Ove Sjöquist, Lars Rydén

Date : 01/07/2002 Item size : 599139 bytes

Methods/results: In isolated, constant pressure (CP) perfused guinea pig hearts a step change of arterial pCO2 from 38.6 to 61.4 mm Hg induced a bi-phasic flow response with an early transient ...

Cardiovascular Research, Original Article, Anke Heintz, Thea Koch, Andreas Deussen

Date : 01/04/2005 Item size : 258820 bytes

Methods and results We used spectral analysis of systolic blood pressure (SBP) variability in mice chronically equipped with telemetry implants to identify frequency ranges (0.050.4 Hz; very low ...

Cardiovascular Research, Original Article, Fanny Desjardins, Irina Lobysheva, Michel Pelat, Bernard Gallez, Olivier Feron, Chantal Dessy, Jean-Luc Balligand

Date : 01/08/2008 Item size : 271138 bytes

[...]NO production by endothelial cells was significantly reduced by ectopic expression of PMCA. Conclusion Our results show strong evidence for a novel functional interaction between endogenous ...

Cardiovascular Research, Original Article, MaryLouisa Holton, Tamer M.A. Mohamed, Delvac Oceandy, Weiguang Wang, Santiago Lamas, Michael Emerson, Ludwig Neyses, Angel L. Armesilla

Date : 01/08/2010 Item size : 257924 bytes

Abstract Objective: Peroxynitrite (ONOO is an oxidant formed from the rapid reaction of superoxide and nitric oxide (NO) at sites of inflammation. The literature reports conflicting data on the ...

Cardiovascular Research, Original Article, Angie S. Brown, Maria A. Moro, Jean Marc Masse, Elizabeth M. Cramer, Marek Radomski, Victor Darley-Usmar

Date : 01/11/1998 Item size : 195310 bytes

Abstract The ability of the endothelium to produce nitric oxide, which induces generation of cyclic guanosine monophosphate (cGMP) that activates cGMP-dependent protein kinase (PKG-I), in vascular ...

Cardiovascular Research, TOPICAL REVIEW, Hassan Sellak, Chung-sik Choi, Nupur B. Dey, Thomas M. Lincoln

Date : 01/02/2013 Item size : 502834 bytes