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The nomenclature of pulmonary hypertension has been updated over the years, reflecting different categories of pulmonary hypertension that may require unique treatments.1,2 Although the aetiologies ...

Cardiovascular Research, REVIEWS: FOCUS ON INORGANIC NITRITE AND NITRATE, Brian S. Zuckerbraun, Patricia George, Mark T. Gladwin

Date : 15/02/2011 Item size : 505144 bytes

[...]Ca2+ influx may stimulate the activity of a constitutive nitric oxide synthase, which catalyses the production of nitric oxide (NO).1 Ca2+ entry may also activate phospholipase A2, a key enzyme ...

Cardiovascular Research, Original Article, Jun-Hao Huang, Guo-Wei He, Hong-Mei Xue, Xiao-Qiang Yao, Xiao-Cheng Liu, Malcolm John Underwood, Qin Yang

Date : 01/08/2011 Item size : 303330 bytes

Preconditioning, a series of transient intervals of ischaemia and reperfusion applied before the lethal index ischaemic event, sets in motion molecular and cellular mechanisms that increase ...

Cardiovascular Research, Review, Asger Granfeldt, David J. Lefer, Jakob Vinten-Johansen

Date : 15/07/2009 Item size : 648421 bytes

[...]cell therapy is faced with a number of challenges, including survival of the transplanted cells in the infarct region, which is characterized by abundant levels of oxidants and lack of a ...

Cardiovascular Research, Original Article, Mahmood Khan, Sarath Meduru, Rajan Gogna, Esha Madan, Lucas Citro, Muthulakshmi L. Kuppusamy, Muzzammil Sayyid, Mahmoud Mostafa, Robert L. Hamlin, Periannan ...

Date : 01/01/2012 Item size : 322521 bytes

Methods: NO synthase activity was measured by the conversion of radioactive arginine into citrulline in extracts of isolated perfused rabbit hearts submitted to low-flow ischaemia and ...

Cardiovascular Research, Original Article, Christophe Depré, Lionel Fiérain, Louis Hue

Date : 01/01/1997 Item size : 248187 bytes

Abstract Excessive production and/or inadequate removal of reactive oxygen species, especially superoxide anion (O2 have been implicated in the pathogenesis of many cardiovascular diseases, including ...

Cardiovascular Research, Review, Tohru Fukai, Rodney J Folz, Ulf Landmesser, David G Harrison

Date : 01/08/2002 Item size : 408641 bytes

Abstract Objective: Because statins promote endogenous nitric oxide (NO) production in vessels by increasing endothelial nitric oxide synthase (eNOS), we evaluated the clinical benefit and efficiency ...

Cardiovascular Research, Original Article, Jean-Noel Trochu, Seema Mital, Xiao-ping Zhang, Xiaobin Xu, Manuel Ochoa, James K Liao, Fabio A Recchia, Thomas H Hintze

Date : 01/11/2003 Item size : 293750 bytes

1 eNOS Nitric oxide: Since the discovery of an endothelium-derived relaxing factor (EDRF) by Furchgott and Zawadzki [1], which was later identified as nitric oxide (NO) [24], it has become clear ...

Cardiovascular Research, Review, Ingrid Fleming, Rudi Busse

Date : 15/08/1999 Item size : 432786 bytes

Abstract Objective: We have shown previously that there is a relative nitric oxide deficiency at the level of vascular endothelium in the stroke-prone spontaneously hypertensive rat (SHRSP), a model ...

Cardiovascular Research, Original Article, M.Yvonne Alexander, M.Julia Brosnan, Carlene A Hamilton, Paul Downie, Alison M Devlin, Fiona Dowell, William Martin, Howard M Prentice, Timothy ...

Date : 15/08/1999 Item size : 290659 bytes

Abstract The discovery in 1990 that nitric oxide (NO) acts as a neuromodulator within the central and peripheral nervous system triggered intensive research which considerably extended our ...

Cardiovascular Research, Review, Johannes Zanzinger

Date : 15/08/1999 Item size : 656362 bytes