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[...]there is some evidence that the UPS itself modulates the activity of endothelial nitric oxide synthase, the key enzyme of vascular homeostasis, interacts with other vasoactive mediators involved ...

Cardiovascular Research, Review, Karl Stangl, Verena Stangl

Date : 15/01/2010 Item size : 509363 bytes

Attenuation of EC responsiveness to insulin results from T-cad-mediated chronic activation of the Akt/mTOR-dependent negative feedback loop of the insulin cascade and enhanced degradation of the ...

Cardiovascular Research, Original Article, Maria Philippova, Manjunath B. Joshi, Dennis Pfaff, Emmanouil Kyriakakis, Kseniya Maslova, Paul Erne, Thérèse J. Resink

Date : 01/03/2012 Item size : 312788 bytes

Phytosterols are structurally similar and functionally analogous to cholesterol.1,2 Phytosterols can lower blood cholesterol by reducing the absorption of cholesterol,1,3 which is one of major risk ...

Cardiovascular Research, Vascular biology and angiogenesis, Chao Yang, Zhen Yu Chen, Siu Ling Wong, Jian Liu, Yin Tong Liang, Chi Wai Lau, Hung Kay Lee, Yu Huang, Suk Ying Tsang

Date : 01/03/2013 Item size : 423287 bytes

[...]we review new approaches to investigation of the glycocalyx barrier properties in cultured endothelial monolayers and in whole-body investigations. Introduction: multilevel studies of vascular ...

Cardiovascular Research, SPOTLIGHT REVIEWS, Fitz-Roy E. Curry, Roger H. Adamson

Date : 15/07/2010 Item size : 482699 bytes

Abstract Virtually all cell types within the myocardium express caveolae, where cell-specific isoforms of caveolin both maintain the structural organisation of these cholesterol-rich of the ...

Cardiovascular Research, Review in Review Focus Series on Caveolae in Cardiovascular Signaling, Olivier Feron, Jean-Luc Balligand

Date : 01/03/2006 Item size : 389211 bytes

There is mounting evidence that thrombin acts as a powerful modulator of many processes like regulation of vascular tone, permeability, migration and proliferation of VSMC, recruitment of monocytes ...

Cardiovascular Research, Review, Julian Ilcheff Borissoff, Henri M.H. Spronk, Sylvia Heeneman, Hugo ten Cate

Date : 01/06/2009 Item size : 584450 bytes

Abstract Aims Pulmonary arterial hypertension (PAH) is a progressive lung disease characterized by pulmonary vasoconstriction and vascular remodelling, leading to increased pulmonary vascular ...

Cardiovascular Research, Original Article, Philip M. Bauer, Eileen M. Bauer, Natasha M. Rogers, Mingyi Yao, Monica Feijoo-Cuaresma, Joseph M. Pilewski, Hunter C. Champion, Brian S. Zuckerbraun, Maria ...

Date : 15/03/2012 Item size : 350153 bytes

[...]NO production by endothelial cells was significantly reduced by ectopic expression of PMCA. Conclusion Our results show strong evidence for a novel functional interaction between endogenous ...

Cardiovascular Research, Original Article, MaryLouisa Holton, Tamer M.A. Mohamed, Delvac Oceandy, Weiguang Wang, Santiago Lamas, Michael Emerson, Ludwig Neyses, Angel L. Armesilla

Date : 01/08/2010 Item size : 257924 bytes

Abstract The ability of the endothelium to produce nitric oxide, which induces generation of cyclic guanosine monophosphate (cGMP) that activates cGMP-dependent protein kinase (PKG-I), in vascular ...

Cardiovascular Research, TOPICAL REVIEW, Hassan Sellak, Chung-sik Choi, Nupur B. Dey, Thomas M. Lincoln

Date : 01/02/2013 Item size : 502834 bytes

Rapamycin also impaired cell mobility, as assessed by a wound test, and promoted the formation of actin stress fibres, as determined with confocal microscopy. [...]the inhibitor prolonged ...

Cardiovascular Research, Original Article, Amelia Barilli, Rossana Visigalli, Roberto Sala, Gian C. Gazzola, Alessandro Parolari, Elena Tremoli, Sabrina Bonomini, Alexandra Simon, Ellen I. Closs, ...

Date : 01/06/2008 Item size : 295259 bytes