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[...]there is some evidence that the UPS itself modulates the activity of endothelial nitric oxide synthase, the key enzyme of vascular homeostasis, interacts with other vasoactive mediators involved ...

Cardiovascular Research, Review, Karl Stangl, Verena Stangl

Date : 15/01/2010 Item size : 509363 bytes

Attenuation of EC responsiveness to insulin results from T-cad-mediated chronic activation of the Akt/mTOR-dependent negative feedback loop of the insulin cascade and enhanced degradation of the ...

Cardiovascular Research, Original Article, Maria Philippova, Manjunath B. Joshi, Dennis Pfaff, Emmanouil Kyriakakis, Kseniya Maslova, Paul Erne, Thérèse J. Resink

Date : 01/03/2012 Item size : 312788 bytes

There is mounting evidence that thrombin acts as a powerful modulator of many processes like regulation of vascular tone, permeability, migration and proliferation of VSMC, recruitment of monocytes ...

Cardiovascular Research, Review, Julian Ilcheff Borissoff, Henri M.H. Spronk, Sylvia Heeneman, Hugo ten Cate

Date : 01/06/2009 Item size : 584450 bytes

[...]Ca2+ influx may stimulate the activity of a constitutive nitric oxide synthase, which catalyses the production of nitric oxide (NO).1 Ca2+ entry may also activate phospholipase A2, a key enzyme ...

Cardiovascular Research, Original Article, Jun-Hao Huang, Guo-Wei He, Hong-Mei Xue, Xiao-Qiang Yao, Xiao-Cheng Liu, Malcolm John Underwood, Qin Yang

Date : 01/08/2011 Item size : 303330 bytes

Abstract Objective: Because statins promote endogenous nitric oxide (NO) production in vessels by increasing endothelial nitric oxide synthase (eNOS), we evaluated the clinical benefit and efficiency ...

Cardiovascular Research, Original Article, Jean-Noel Trochu, Seema Mital, Xiao-ping Zhang, Xiaobin Xu, Manuel Ochoa, James K Liao, Fabio A Recchia, Thomas H Hintze

Date : 01/11/2003 Item size : 293750 bytes

Abstract Objective: We have shown previously that there is a relative nitric oxide deficiency at the level of vascular endothelium in the stroke-prone spontaneously hypertensive rat (SHRSP), a model ...

Cardiovascular Research, Original Article, M.Yvonne Alexander, M.Julia Brosnan, Carlene A Hamilton, Paul Downie, Alison M Devlin, Fiona Dowell, William Martin, Howard M Prentice, Timothy ...

Date : 15/08/1999 Item size : 290659 bytes

Tel: +44 121 5075080, Fax: +44 121 554 4083, Email: Search for more papers by this author Wrigley Benjamin J., University of Birmingham Centre for Cardiovascular Sciences, City ...

European Journal of Heart Failure, Shantsila, Eduard, Wrigley, Benjamin J., Blann, Andrew D., Gill, Paramjit S., Lip, Gregory Y.H.

Date : 01/08/2012 Item size : 202684 bytes

Abstract Endothelial production of nitric oxide (nitrogen monoxide, NO) has become a major research area in vascular biology. The aim of this review is to examine the cellular and molecular ...

Cardiovascular Research, Review, Michael T Gewaltig, Georg Kojda

Date : 01/08/2002 Item size : 486616 bytes

[...]Seta et al.17 reported significantly higher TNF-α levels in patients in the early stages of HF (NYHA II) compared with normal subjects. [...]a linear association between TNF-α levels and ...

Cardiovascular Research, Review, Stavros Apostolakis, Gregory Y.H. Lip, Eduard Shantsila

Date : 01/03/2010 Item size : 532531 bytes

Metabolic factors associated with the diabetic state itself, such as hyperglycaemia, are likely to contribute to the increased cardiovascular risk in diabetic patients.1 Endothelial dysfunction is ...

Cardiovascular Research, Editorial, Assunta Pandolfi, Natalia Di Pietro

Date : 01/04/2010 Item size : 178079 bytes