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There is mounting evidence that thrombin acts as a powerful modulator of many processes like regulation of vascular tone, permeability, migration and proliferation of VSMC, recruitment of monocytes ...

Cardiovascular Research, Review, Julian Ilcheff Borissoff, Henri M.H. Spronk, Sylvia Heeneman, Hugo ten Cate

Date : 01/06/2009 Item size : 584450 bytes

In addition to their lipid-lowering effects, one central biological action of statins is their ability to ameliorate the impaired bioavailability of NO.1 Mechanistically, this occurs through ...

Cardiovascular Research, Editorial, Stephan H. Schirmer, Christian M. Werner, Ulrich Laufs, Michael Böhm

Date : 01/06/2012 Item size : 181712 bytes

Convincing data from animal and in vitro models exist to indicate that endothelial dysfunction in diabetes may be related to hyperglycaemic pseudohypoxia, activation of protein kinase C, increased ...

Cardiovascular Research, Review, Coen D.A Stehouwer, Jan Lambert, A.J.M Donker, Victor W.M van Hinsbergh

Date : 01/04/1997 Item size : 262032 bytes

Three distinct NO synthase (NOS) isoforms, each encoded for by separate genes, have now been identified [14]. nNOS (or neuronal NOS, NOS1) and eNOS (or endothelial NOS, NOS3) are constitutive, ...

Cardiovascular Research, Update review, Ajay M Shah

Date : 01/01/2000

Abstract Aims Recent studies have reported that the calcium-dependent protease calpain is involved in hyperglycaemia-induced endothelial dysfunction and that the Na+/H+ exchanger (NHE) is responsible ...

Cardiovascular Research, Original Article, Shuangxi Wang, Qisheng Peng, Junhua Zhang, Liying Liu

Date : 01/11/2008

In one clinical trial, 4444 patients were carefully studied and not only was simvastatin shown to be safe and effective in lowering circulating cholesterol, it also significantly improved survival in ...

Cardiovascular Research, Review, Allan M Lefer, Rosario Scalia, David J Lefer

Date : 01/02/2001

Methods and results In both cultured endothelial cells and blood vessels isolated from rat aorta, berberine concentration dependently enhanced phosphorylation of endothelial nitric oxide synthase ...

Cardiovascular Research, Original Article, Yiqun Wang, Yu Huang, Karen S.L. Lam, Yiming Li, Wing Tak Wong, Hongying Ye, Chi-Wai Lau, Paul M. Vanhoutte, Aimin Xu

Date : 01/06/2009

Most importantly, the demonstration was based on human data from a study in patients with peripheral vascular disease.3 The authors' reasoning was grounded on previous knowledge of the metabolism of ...

Cardiovascular Research, EDITORIALS: SPOTLIGHT ON LANDMARK PAPERS IN, Jean-Luc Balligand

Date : 01/11/2012

Increased activity of arginase may reduce the availability of l-arginine for NO synthase, thus reducing NO production, increasing formation of reactive oxygen species, and leading ultimately to ...

Cardiovascular Research, TOPICAL REVIEW, John Pernow, Christian Jung

Date : 01/06/2013

[...]endothelial dysfunction, which underlies many cardiovascular disease conditions, can trigger acute vascular events including vasospasm, thrombosis or restenosis leading to ischaemia. In ...

Cardiovascular Research, Review, Mahinda Y Abeywardena, Richard J Head

Date : 01/12/2001