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With the increased interest in using nitric oxide therapy to treat a number of human diseases, the understanding of the physiological properties unique to peroxynitrite as an important nitric oxide ...

Cardiovascular Research, Review, Russell S Ronson, Masanori Nakamura, Jakob Vinten-Johansen

Date : 01/10/1999 Item size : 442561 bytes

The nomenclature of pulmonary hypertension has been updated over the years, reflecting different categories of pulmonary hypertension that may require unique treatments.1,2 Although the aetiologies ...

Cardiovascular Research, REVIEWS: FOCUS ON INORGANIC NITRITE AND NITRATE, Brian S. Zuckerbraun, Patricia George, Mark T. Gladwin

Date : 15/02/2011 Item size : 505144 bytes

Abstract Aims Vascular calcification often occurs with advancing age, atherosclerosis, and metabolic disorders such as diabetes mellitus and end-stage renal disease. Vascular calcification is ...

Cardiovascular Research, Original Article, Yosuke Kanno, Takeshi Into, Charles J. Lowenstein, Kenji Matsushita

Date : 01/01/2008 Item size : 286326 bytes

Yet, while modulation of cGMP-PKG has entered clinical practice for treating pulmonary hypertension or erectile dysfunction, translation of promising studies in experimental HF to clinical success ...

Cardiovascular Research, Review, Peter P. Rainer, David A. Kass

Date : 15/07/2016 Item size : 575491 bytes

The objective of the present study was to compare responses of microvascular non-collaterals, native collaterals and stimulated collaterals in the heart to three vasodilators which act through ...

Cardiovascular Research, Original Article, Kathryn G Lamping, Daniel W Nuno, Leonard A Brooks, Mikio Fujii

Date : 01/08/1997 Item size : 222405 bytes

Abstract There is convincing evidence that the prevalence of erectile dysfunction is increased among men with ischaemic heart disease. KeywordsNitric oxideErectile dysfunctionDiabetes ...

Cardiovascular Research, Original Article, Mark E. Sullivan, Cecil S. Thompson, Michael R. Dashwood, Masood A. Khan, Jamie Y. Jeremy, Robert J. Morgan, Dimitri P. Mikhailidis

Date : 15/08/1999 Item size : 375578 bytes

Abstract The Ras superfamily of small GTPases cycle between inactive GDP-bound and active GTP-bound states to modulate a diverse array of processes involved in cellular growth control. Guanine ...

Cardiovascular Research, Review, Kimberly W. Raines, Marcelo G. Bonini, Sharon L. Campbell

Date : 15/07/2007 Item size : 538983 bytes

Mice lacking the endothelial isoform are hypertensive, have endothelial dysfunction and show a more severe outcome in response to vascular injury, to stroke and cerebral ischaemia, and to ...

Cardiovascular Research, REVIEW ARTICLES, Victor W.T. Liu, Paul L. Huang

Date : 01/01/2008 Item size : 592603 bytes

Abstract Objective: In sinoatrial (SA) node cells, nitric oxide (NO) exerts a dual effect on the hyperpolarization-activated current, If, i.e. in basal conditions NO enhances If whereas in the ...

Cardiovascular Research, Original Article, Simon M Bryant, Claire E Sears, Lauren Rigg, Derek A Terrar, Barbara Casadei

Date : 01/07/2001

The SNAP effect on ICa,L involved activation of soluble guanylate cyclase and protein kinase A. Specific inhibition of phosphodiesterase (PDE)3 with cilostamide (1 µM) enhanced ICa,L to a similar ...

Cardiovascular Research, Ion channels and arrhythmias, Nadiia Rozmaritsa, Torsten Christ, David R. Van Wagoner, Hannelore Haase, Johannes-Peter Stasch, Klaus Matschke, Ursula Ravens

Date : 01/03/2014