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Abstract Aims Endothelial dysfunction is caused by reduced nitric oxide (NO) bioavailability and/or over-produced reactive oxygen species (ROS). The present study investigated a vascular benefit of ...

Cardiovascular Research, Original Article, Wai San Cheang, Wing Tak Wong, Xiao Yu Tian, Qin Yang, Hung Kay Lee, Guo-Wei He, Xiaoqiang Yao, Yu Huang

Date : 01/11/2011

Abstract Objective: Regular exercise is recommended for the non-pharmacological treatment of hypertension, but the mechanisms underlying the lowering of blood pressure remain controversial. [...]we ...

Cardiovascular Research, Original Article, Pertti Arvola, Xiumin Wu, Mika Kähönen, Heikki Mäkynen, Asko Riutta, István Mucha, Tiina Solakivi, Heikki Kainulainen, Ilkka Pörsti

Date : 01/09/1999

Abstract Objectives: Our aim was to investigate the potential therapeutic role of endothelial nitric oxide synthase (eNOS) in the modulation of cardiac O2 consumption induced by the angiotensin ...

Cardiovascular Research, Original Article, Kit E Loke, Eric J Messina, Edward G Shesely, Gabor Kaley, Thomas H Hintze

Date : 01/01/2001

Ultraviolet light induced a relaxation in arteries treated with l-NMMA+Indo (37.0±5.2%, n=9) which was sensitive to OxyHb (15.2±10.9%, n=4), and barium+ouabain (6.39±2.7%, n=4), but not ...

Cardiovascular Research, Original Article, Sharmila Chauhan, Awahan Rahman, Holger Nilsson, Lucie Clapp, Raymond MacAllister, Amrita Ahluwalia

Date : 01/01/2003

Abstract Objective: Urocortin is a peptide structurally related to corticotropin releasing factor (CRF), and the present study was performed to examine the effects of diabetes mellitus on the ...

Cardiovascular Research, Original Article, Elena Sanz, Nuria Fernández, Luis Monge, Belén Climent, Godofredo Diéguez, Angel Luis García-Villalón

Date : 01/06/2003

Abstract Objective: Angiotensin-converting enzyme (ACE) inhibition has been shown to restore impaired endothelial function in hypertension, but the roles of different mediators in enhanced ...

Cardiovascular Research, Original Article, Nina Hutri-Kähönen, Mika Kähönen, Jari-Petteri Tolvanen, Wu Xiumin, Kirsimarja Sallinen, Ilkka Pörsti

Date : 01/01/1997

Abstract Objective: Since the effects of angiotensin II receptor antagonism on arterial function in nitric oxide (NO)-deficient hypertension are unknown, we investigated the influence of losartan ...

Cardiovascular Research, Original Article, Jarkko Kalliovalkama, Pasi Jolma, Jari-Petteri Tolvanen, Mika Kähönen, Nina Hutri-Kähönen, Xiumin Wu, Päivi Holm, Ilkka Pörsti

Date : 01/06/1999

Abstract Objectives: Estrogen exerts cardiac protection via multiple cellular mechanisms. Conclusion: In endothelium-intact rat mesenteric arteries pretreatment with low concentrations of ...

Cardiovascular Research, Original Article, Hoi Yun Chan, Xiaoqiang Yao, Suk Ying Tsang, Jean-Pierre Bourreau, Franky Leung Chan, Yu Huang

Date : 15/02/2002

To clarify the mechanism of action of TNF-α on myocardium, we investigated the possible role of platelet-activating factor (PAF) and nitric oxide (NO) as secondary mediators of the depressant ...

Cardiovascular Research, Original Article, Giuseppe Alloatti, Claudia Penna, Antonella De Martino, Giuseppe Montrucchio, Giovanni Camussi

Date : 01/03/1999

Abstract Objective: In this study the role of 17β-estradiol (E2) in the regulation of endothelin-1 (ET-1) mRNA expression and secretion was investigated in cultured human umbilical vein ...

Cardiovascular Research, Original Article, A.Serpil Bilsel, Hadi Moini, Erkan Tetik, Fehime Aksungar, Bogaç Kaynak, Ayse Özer

Date : 01/06/2000