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Abstract Objective: Peroxynitrite (ONOO is an oxidant formed from the rapid reaction of superoxide and nitric oxide (NO) at sites of inflammation. The literature reports conflicting data on the ...

Cardiovascular Research, Original Article, Angie S. Brown, Maria A. Moro, Jean Marc Masse, Elizabeth M. Cramer, Marek Radomski, Victor Darley-Usmar

Date : 01/11/1998 Item size : 195310 bytes

Abstract The ability of the endothelium to produce nitric oxide, which induces generation of cyclic guanosine monophosphate (cGMP) that activates cGMP-dependent protein kinase (PKG-I), in vascular ...

Cardiovascular Research, TOPICAL REVIEW, Hassan Sellak, Chung-sik Choi, Nupur B. Dey, Thomas M. Lincoln

Date : 01/02/2013 Item size : 502834 bytes

OBJECTIVE--To determine the optimum conditions for the demonstration of an antiplatelet effect of nitric oxide and to use these conditions to elucidate the effects of a transdermal glyceryl ...

British Heart Journal, Research Article, R Andrews, J A May, J Vickers, S Heptinstall

Date : 01/12/1994

Dr Dimitris Tousoulis Athens University Medical School, S Karagiorga Street 69, 166 75, Glifada, Athens, Greece; The endothelium regulates vascular homeostasis through the release ...

Heart, Education in Heart, D Tousoulis, C Antoniades, C Stefanadis

Date : 01/04/2005

CardioPulse ArticlesEuropean Commissioners petitioned for clean air and reduced noise pollutionProfessor Sir Salvador Moncada MD PhD FRSShould we screen cardiovascular patients for thyroid ...

European Heart Journal, CardioPulse

Date : 14/12/2015 Item size : 168114 bytes

Gender-related differences in the risk of cardiovascular diseases have been well recognized with premenopausal women exhibiting a lower risk compared to age-matched men [1]. Estrogen is implicated ...

Cardiovascular Research, Editorial, Xiao-Jun Du

Date : 01/10/2002 Item size : 228965 bytes

In addition to regulating vascular tone, it is now appreciated that endothelium-derived NO also acts to inhibit platelet activity, vascular smooth muscle cell growth, and adhesion of inflammatory ...

Cardiovascular Research, Review, Douglas Tomasian, John F. Keaney, Joseph A. Vita

Date : 18/08/2000 Item size : 576226 bytes

Abstract Platelet and endothelial production of bioactive nitric oxide (NO) is known to be impaired in acute coronary syndromes, thus compounds that release NO are useful candidates to restore ...

Cardiovascular Research, Original Article, Gemma Vilahur, María Isabel Baldellou, Estefania Segalés, Eduardo Salas, Lina Badimon

Date : 01/03/2004

Abstract Objective Carbon monoxide (CO) modulates several physiological functions through activation of a cGMP-dependent pathway similar to that of nitric oxide (NO). Here we investigated the ...

Cardiovascular Research, Original Article, Stefan Chlopicki, Rafal Olszanecki, Ewa Marcinkiewicz, Magdalena Lomnicka, Roberto Motterlini

Date : 15/07/2006

Methods: NOS activity was determined from the conversion of l-[3H]arginine to l-[3H]citrulline, both basally and following β-AR stimulation, in platelets from healthy human subjects following both ...

Cardiovascular Research, Original Article, Peter D. O'Kane, Lindsay R. Queen, Yong Ji, Vikash Reebye, Paula Stratton, Graham Jackson, Albert Ferro

Date : 01/07/2003