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[...]Ca2+ influx may stimulate the activity of a constitutive nitric oxide synthase, which catalyses the production of nitric oxide (NO).1 Ca2+ entry may also activate phospholipase A2, a key enzyme ...

Cardiovascular Research, Original Article, Jun-Hao Huang, Guo-Wei He, Hong-Mei Xue, Xiao-Qiang Yao, Xiao-Cheng Liu, Malcolm John Underwood, Qin Yang

Date : 01/08/2011 Item size : 303330 bytes

Abstract Administration of nitric oxide (NO), NO donors or drugs that enhance NO realease (statins, calcium antagonists, ACE-inhibitors, dexamethasone) prior to ischemia protects the myocardium ...

Cardiovascular Research, Review, Rainer Schulz, Malte Kelm, Gerd Heusch

Date : 15/02/2004 Item size : 581140 bytes

Introduction Atrial fibrillation (AF) is the most common cardiac arrhythmia and its prevalence will continue to increase over the next decades due to ageing of the population.1 Over the last years ...

Europace, BASIC SCIENCE, Ilse Lenaerts, Ronald B. Driesen, Nerea Hermida Blanco, Patricia Holemans, Hein Heidbüchel, Stefan Janssens, Jean-Luc Balligand, Karin R. Sipido, Rik Willems

Date : 01/05/2013 Item size : 244478 bytes

[...]lysine acetyl transferase (KAT) activity associated with Nup153 was higher in mdx hearts paralleling increased binding with the lysine acetylases P300/CBP-associated factor (PCAF) and ...

Cardiovascular Research, Original Article, Simona Nanni, Agnese Re, Cristian Ripoli, Aoife Gowran, Patrizia Nigro, Domenico D’Amario, Antonio Amodeo, Filippo Crea, Claudio Grassi, Alfredo ...

Date : 01/11/2016 Item size : 368731 bytes

Abstract Objective: This study is aimed to explore whether gender plays a role in the generation of nitric oxide (NO) and superoxide anion (O2 in microvessels of hypertensive rats (SHR), as well as ...

Cardiovascular Research, Original Article, Ana Paula V Dantas, Maria do Carmo P Franco, Michele M Silva-Antonialli, Rita C.A Tostes, Zuleica B Fortes, Dorothy Nigro, Maria Helena C Carvalho

Date : 01/01/2004 Item size : 252323 bytes

Abstract Aims Previously, we showed an enhanced excitatory (N-methyl d-aspartate receptor-NR1) and decreased inhibitory neuronal nitric oxide (NO) synthase (nNOS) influence within the paraventricular ...

Cardiovascular Research, Original Article, Neeru M. Sharma, Hong Zheng, Parmender P. Mehta, Yi-Fan Li, Kaushik P. Patel

Date : 01/11/2011 Item size : 307597 bytes

Abstract Objective: Endothelial NADPH oxidase is a major source of superoxide in blood vessels and is implicated in the oxidative stress accompanying vascular diseases, including ...

Cardiovascular Research, Original Article, Stavros Selemidis, Gregory J. Dusting, Hitesh Peshavariya, Barbara K. Kemp-Harper, Grant R. Drummond

Date : 15/07/2007 Item size : 256835 bytes

[...]pharmacological inhibition of nNOS with 7-nitroindazole reversed this impairment in WT mice. cNOS (eNOS+nNOS) activity was elevated in septic WT mice; Western blots indicated that this occurred ...

Cardiovascular Research, Original Article, Darcy Lidington, Fuyan Li, Karel Tyml

Date : 01/04/2007 Item size : 262732 bytes

Abstract Objective: The inducible isoform of nitric oxide synthase (iNOS) is known to be a trigger of the heat stress (HS)-induced cardioprotection. Since iNOS also appears to mediate various forms ...

Cardiovascular Research, Original Article, Claire Arnaud, Diane Godin-Ribuot, Serge Bottari, André Peinnequin, Marie Joyeux, Pierre Demenge, Christophe Ribuot

Date : 01/04/2003 Item size : 295317 bytes

Abstract Aims Valsartan, a selective angiotensin II type 1 receptor (AT1R) blocker, has beneficial effects in the cardiovascular system in part by its increase of nitric oxide (NO) bioavailability, ...

Cardiovascular Research, Original Article, Kuo-Hui Su, Jin-Yi Tsai, Yu Ru Kou, An-Na Chiang, Sheng-Huang Hsiao, Yuh-Lin Wu, Hsin-Han Hou, Ching-Chian Pan, Song-Kun Shyue, Tzong-Shyuan Lee

Date : 01/06/2009