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Other effectors possibly contributing to cardioprotection by Ado or PC, and which seem particularly involved in the delayed (second window of) protection, include MAP kinases, heat shock proteins and ...

Cardiovascular Research, Review, Kanigula Mubagwa, Willem Flameng

Date : 01/10/2001 Item size : 701190 bytes

Abstract The ability of the endothelium to produce nitric oxide, which induces generation of cyclic guanosine monophosphate (cGMP) that activates cGMP-dependent protein kinase (PKG-I), in vascular ...

Cardiovascular Research, TOPICAL REVIEW, Hassan Sellak, Chung-sik Choi, Nupur B. Dey, Thomas M. Lincoln

Date : 01/02/2013 Item size : 502834 bytes

Abstract It is well recognized that insulin resistance found in patients with type 2 diabetes and obesity is a major risk factor for cardiovascular disease. Since its discovery in the 1920s, insulin ...

Cardiovascular Research, REVIEWS: FOCUS ON INORGANIC NITRITE AND NITRATE, Qiujun Yu, Feng Gao, Xin L. Ma

Date : 15/02/2011 Item size : 415186 bytes

Pharmacological adenosine receptor blockade during preconditioning abolishes the acquisition of delayed protection, while transient adenosine A1 or A3 receptor activation fully recapitulates ...

Cardiovascular Research, Review, G.F Baxter

Date : 15/08/2002 Item size : 442878 bytes

Abstract Administration of nitric oxide (NO), NO donors or drugs that enhance NO realease (statins, calcium antagonists, ACE-inhibitors, dexamethasone) prior to ischemia protects the myocardium ...

Cardiovascular Research, Review, Rainer Schulz, Malte Kelm, Gerd Heusch

Date : 15/02/2004 Item size : 581140 bytes

[...]AT2 receptor stimulation inhibits growth and promotes apoptosis, an important mechanism during development and tissue remodeling. [...]ANG stimulates the release of nitric oxide (NO)/cGMP via ...

Cardiovascular Research, Review, Olaf Jöhren, Andreas Dendorfer, Peter Dominiak

Date : 01/06/2004 Item size : 423872 bytes

Methods: Single L-type calcium channels were recorded in the cell attached configuration of the patch clamp technique in isolated mouse ventricular myocytes. Results: The β-adrenoceptor agonist ...

Cardiovascular Research, Original Article, Gunnar Klein, Helmut Drexler, Frank Schröder

Date : 01/12/2000 Item size : 249914 bytes

Numerous clinical trials focused on therapeutic angiogenesis for the treatment of tissue ischaemia have not been as successful as those of preclinical studies. [...]additional studies are needed to ...

Cardiovascular Research, Review, Shyamal C. Bir, Yan Xiong, Christopher G. Kevil, Jincai Luo

Date : 01/07/2012 Item size : 723063 bytes

Time for primary review 13 days. 1 Introduction Vascular smooth muscle cell (VSMC) proliferation is an important component of vessel wall remodelling in response to injury, for example, after ...

Cardiovascular Research, Review, Jamie Y. Jeremy, Daniel Rowe, Alison M. Emsley, Andrew C. Newby

Date : 15/08/1999 Item size : 746881 bytes

Abstract Aims Vascular calcification often occurs with advancing age, atherosclerosis, and metabolic disorders such as diabetes mellitus and end-stage renal disease. Vascular calcification is ...

Cardiovascular Research, Original Article, Yosuke Kanno, Takeshi Into, Charles J. Lowenstein, Kenji Matsushita

Date : 01/01/2008 Item size : 286326 bytes