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Phytosterols are structurally similar and functionally analogous to cholesterol.1,2 Phytosterols can lower blood cholesterol by reducing the absorption of cholesterol,1,3 which is one of major risk ...

Cardiovascular Research, Vascular biology and angiogenesis, Chao Yang, Zhen Yu Chen, Siu Ling Wong, Jian Liu, Yin Tong Liang, Chi Wai Lau, Hung Kay Lee, Yu Huang, Suk Ying Tsang

Date : 01/03/2013 Item size : 423287 bytes

Introduction Nearly twenty years after its initial description, the phenomenon of ischemic preconditioning, whereby episodes of intermittent sublethal ischemia and reperfusion confer resistance ...

Cardiovascular Research, Review, Derek J. Hausenloy, Derek M. Yellon

Date : 01/05/2006 Item size : 525135 bytes

Abstract Excessive production and/or inadequate removal of reactive oxygen species, especially superoxide anion (O2 have been implicated in the pathogenesis of many cardiovascular diseases, including ...

Cardiovascular Research, Review, Tohru Fukai, Rodney J Folz, Ulf Landmesser, David G Harrison

Date : 01/08/2002 Item size : 408641 bytes

There is evidence that as the endothelium ages, it is exposed to the damaging effects of raised blood pressure and increased concentrations of cholesterol, glucose, homocysteine, to products of the ...

Heart, Mini-symposium, L C Jones, A D Hingorani

Date : 01/10/2005

The beneficial actions of COX-2 appear to be mediated by the synthesis of PGE2 and/or PGI2. Since inhibition of iNOS in preconditioned myocardium blocks COX-2 activity whereas inhibition of COX-2 ...

Cardiovascular Research, Review, Roberto Bolli, Ken Shinmura, Xian-Liang Tang, Eitaro Kodani, Yu-Ting Xuan, Yiru Guo, Buddhadeb Dawn

Date : 15/08/2002 Item size : 570075 bytes

Pharmacological adenosine receptor blockade during preconditioning abolishes the acquisition of delayed protection, while transient adenosine A1 or A3 receptor activation fully recapitulates ...

Cardiovascular Research, Review, G.F Baxter

Date : 15/08/2002 Item size : 442878 bytes

The role of reactive oxygen species and redox signalling in cardiovascular disease Reactive oxygen species (ROS) are generated during regulated physiological processes, and play a critical function ...

European Heart Journal, Clinical update, Keyvan Karimi Galougahi, Charalambos Antoniades, Stephen J. Nicholls, Keith M. Channon, Gemma A. Figtree

Date : 01/07/2015 Item size : 398285 bytes

Introduction Atrial fibrillation (AF) is the most common cardiac arrhythmia and its prevalence will continue to increase over the next decades due to ageing of the population.1 Over the last years ...

Europace, BASIC SCIENCE, Ilse Lenaerts, Ronald B. Driesen, Nerea Hermida Blanco, Patricia Holemans, Hein Heidbüchel, Stefan Janssens, Jean-Luc Balligand, Karin R. Sipido, Rik Willems

Date : 01/05/2013 Item size : 244478 bytes

Abstract Objective: A poorly characterized phagocyte-type NADPH oxidase, which is reportedly NADH- rather than NADPH-dependent, is a major source of endothelial reactive oxygen species (ROS) ...

Cardiovascular Research, Original Article, Jian-Mei Li, Ajay M. Shah

Date : 01/12/2001 Item size : 270633 bytes

[...]endothelial mitochondria are centrally involved in maintaining the fine regulatory balance between mitochondrial calcium concentration, reactive oxygen species (ROS) production, and ...

Cardiovascular Research, REVIEWS: FOCUS ON MITOCHONDRIA IN CARDIAC DISEASE, Sean Michael Davidson

Date : 01/10/2010 Item size : 527437 bytes