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Methods/results: In isolated, constant pressure (CP) perfused guinea pig hearts a step change of arterial pCO2 from 38.6 to 61.4 mm Hg induced a bi-phasic flow response with an early transient ...

Cardiovascular Research, Original Article, Anke Heintz, Thea Koch, Andreas Deussen

Date : 01/04/2005 Item size : 258820 bytes

Abstract Objective: The aims were to validate the use of a direct reading NO electrode, to compare the effects of diverse acting drugs on altering coronary flow (CF) and NO release, and to examine ...

Cardiovascular Research, Original Article, Satoshi Fujita, David L Roerig, Zeljko J Bosnjak, David F Stowe

Date : 01/06/1998 Item size : 291609 bytes

Numerous clinical trials focused on therapeutic angiogenesis for the treatment of tissue ischaemia have not been as successful as those of preclinical studies. [...]additional studies are needed to ...

Cardiovascular Research, Review, Shyamal C. Bir, Yan Xiong, Christopher G. Kevil, Jincai Luo

Date : 01/07/2012 Item size : 723063 bytes

Time for primary review 13 days. 1 Introduction Vascular smooth muscle cell (VSMC) proliferation is an important component of vessel wall remodelling in response to injury, for example, after ...

Cardiovascular Research, Review, Jamie Y. Jeremy, Daniel Rowe, Alison M. Emsley, Andrew C. Newby

Date : 15/08/1999 Item size : 746881 bytes

In the vessels of healthy subjects, endothelial cells (ECs) of large conduit arteries express Cx37 and Cx40, whereas Cx43 and (to a much lower extent) Cx45 are mostly expressed by vascular smooth ...

Cardiovascular Research, SPOTLIGHT REVIEWS: SPOTLIGHT ON BIOMECHANICAL FACTORS IN CARDIOVASCULAR DISEASE, Merlijn J. Meens, Anna Pfenniger, Brenda R. Kwak, Mario Delmar

Date : 15/07/2013 Item size : 526340 bytes

Atherosclerosis is epidemiologically linked and causally related to the presence of risk factors Despite their diversity, major risk factors for cardiovascular disease such as hypercholesterolaemia, ...

Cardiovascular Research, Editorial, Raffaele De Caterina, Rosalinda Madonna

Date : 01/03/2009 Item size : 231905 bytes

In the past two decades, nitric oxide (NO), a molecule whose natural biological role was recognized in a relatively recent period [1], has gained wide credit as a possible agent of physiological and ...

Cardiovascular Research, Editorial, A. Cevese

Date : 01/04/2005 Item size : 158483 bytes

In addition to regulating vascular tone, it is now appreciated that endothelium-derived NO also acts to inhibit platelet activity, vascular smooth muscle cell growth, and adhesion of inflammatory ...

Cardiovascular Research, Review, Douglas Tomasian, John F. Keaney, Joseph A. Vita

Date : 18/08/2000 Item size : 576226 bytes

Abstract Objective: The antiapoptotic effect of p21Waf1/Cip1/Sdi1 (p21) was examined in human umbilical vein endothelial cells (HUVEC) exposed to laminar shear stress (SS) or to the nitric oxide ...

Cardiovascular Research, Original Article, Stefania Mattiussi, Paolo Turrini, Lucia Testolin, Fabio Martelli, Germana Zaccagnini, Antonella Mangoni, Laura M Barlucchi, Annalisa Antonini, Barbara ...

Date : 01/03/2004

[...]in the endothelial cells, CaM Kinase II activation has been shown to precede activations of downstream tyrosine kinase and serine/threonine kinase, resulting in changes in gene expression, ...

Cardiovascular Research, REVIEW ARTICLES, Hua Cai, Depei Liu, Joe G.N. Garcia

Date : 01/01/2008