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With the increased interest in using nitric oxide therapy to treat a number of human diseases, the understanding of the physiological properties unique to peroxynitrite as an important nitric oxide ...

Cardiovascular Research, Review, Russell S Ronson, Masanori Nakamura, Jakob Vinten-Johansen

Date : 01/10/1999 Item size : 442561 bytes

Abstract Excessive production and/or inadequate removal of reactive oxygen species, especially superoxide anion (O2 have been implicated in the pathogenesis of many cardiovascular diseases, including ...

Cardiovascular Research, Review, Tohru Fukai, Rodney J Folz, Ulf Landmesser, David G Harrison

Date : 01/08/2002 Item size : 408641 bytes

Abstract Objective: This study is aimed to explore whether gender plays a role in the generation of nitric oxide (NO) and superoxide anion (O2 in microvessels of hypertensive rats (SHR), as well as ...

Cardiovascular Research, Original Article, Ana Paula V Dantas, Maria do Carmo P Franco, Michele M Silva-Antonialli, Rita C.A Tostes, Zuleica B Fortes, Dorothy Nigro, Maria Helena C Carvalho

Date : 01/01/2004 Item size : 252323 bytes

The authors identified increased production of oxygen-derived species (ROS) including superoxide anion and hydrogen peroxide (H2O2) in the lungs of adult but not newborn Alk1+/ mice. Dysfunction of ...

Cardiovascular Research, Editorial, Livius V. d'Uscio

Date : 01/12/2011 Item size : 177916 bytes

Time for primary review 23 days. 1 Introduction Nitric oxide (NO) plays a crucial role in the regulation of vascular tone and maintenance of vascular integrity [13]. [...]nitric oxide reduces ...

Cardiovascular Research, Review, Francesco Cosentino, Thomas F Lüscher

Date : 01/08/1999 Item size : 256397 bytes

Abstract Increased production of reactive oxygen species (ROS) has been implicated in the pathogenesis of cardiovascular diseases. Enzymatic systems such as the mitochondrial respiratory chain, ...

Cardiovascular Research, Review, Hua Cai

Date : 01/10/2005 Item size : 587026 bytes

Methods: In rat mesenteric arteries, isometric tension was recorded in wire myographs, protein expression was evaluated by Western blot and/or immunohistochemistry and NO concentration was measured ...

Cardiovascular Research, Original Article, Raquel Hernanz, María J Alonso, Helle Zibrandtsen, Yolanda Alvarez, Mercedes Salaices, Ulf Simonsen

Date : 01/04/2004 Item size : 295923 bytes

[...]the role of the mitochondrial uncoupling proteins in ischaemia tolerance is discussed. Mitochondria are essential organelles in any tissue, but when oxygen availability is limited they can ...

Cardiovascular Research, REVIEWS: FOCUS ON MITOCHONDRIA IN CARDIAC DISEASE, Susana Cadenas, Julián Aragonés, Manuel O. Landázuri

Date : 01/11/2010 Item size : 633400 bytes

Reperfusion injury is expressed as endothelial and microvascular dysfunction, impaired blood flow, metabolic dysfunction, cellular necrosis, and apoptosis. Postconditioning may also inhibit ...

Cardiovascular Research, Review, Zhi-Qing Zhao, Jakob Vinten-Johansen

Date : 01/05/2006 Item size : 477372 bytes

In addition to regulating vascular tone, it is now appreciated that endothelium-derived NO also acts to inhibit platelet activity, vascular smooth muscle cell growth, and adhesion of inflammatory ...

Cardiovascular Research, Review, Douglas Tomasian, John F. Keaney, Joseph A. Vita

Date : 18/08/2000 Item size : 576226 bytes