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There is mounting evidence that thrombin acts as a powerful modulator of many processes like regulation of vascular tone, permeability, migration and proliferation of VSMC, recruitment of monocytes ...

Cardiovascular Research, Review, Julian Ilcheff Borissoff, Henri M.H. Spronk, Sylvia Heeneman, Hugo ten Cate

Date : 01/06/2009 Item size : 584450 bytes

Abstract The ability of the endothelium to produce nitric oxide, which induces generation of cyclic guanosine monophosphate (cGMP) that activates cGMP-dependent protein kinase (PKG-I), in vascular ...

Cardiovascular Research, TOPICAL REVIEW, Hassan Sellak, Chung-sik Choi, Nupur B. Dey, Thomas M. Lincoln

Date : 01/02/2013 Item size : 502834 bytes

KeywordsBlood pressureCell communicationEndothelial factorsRenal functionTime for primary review 26 days. 1 Introduction There is a widely held view that function of the kidney is the key to ...

Cardiovascular Research, Review, Yuri Kotelevtsev, David J Webb

Date : 15/08/2001 Item size : 344637 bytes

Abstract Excessive production and/or inadequate removal of reactive oxygen species, especially superoxide anion (O2 have been implicated in the pathogenesis of many cardiovascular diseases, including ...

Cardiovascular Research, Review, Tohru Fukai, Rodney J Folz, Ulf Landmesser, David G Harrison

Date : 01/08/2002 Item size : 408641 bytes

Abstract Objective: The aims were to validate the use of a direct reading NO electrode, to compare the effects of diverse acting drugs on altering coronary flow (CF) and NO release, and to examine ...

Cardiovascular Research, Original Article, Satoshi Fujita, David L Roerig, Zeljko J Bosnjak, David F Stowe

Date : 01/06/1998 Item size : 291609 bytes

Time for primary review 13 days. 1 Introduction Vascular smooth muscle cell (VSMC) proliferation is an important component of vessel wall remodelling in response to injury, for example, after ...

Cardiovascular Research, Review, Jamie Y. Jeremy, Daniel Rowe, Alison M. Emsley, Andrew C. Newby

Date : 15/08/1999 Item size : 746881 bytes

Gender-related differences in the risk of cardiovascular diseases have been well recognized with premenopausal women exhibiting a lower risk compared to age-matched men [1]. Estrogen is implicated ...

Cardiovascular Research, Editorial, Xiao-Jun Du

Date : 01/10/2002 Item size : 228965 bytes

Abstract Aims Vascular calcification often occurs with advancing age, atherosclerosis, and metabolic disorders such as diabetes mellitus and end-stage renal disease. Vascular calcification is ...

Cardiovascular Research, Original Article, Yosuke Kanno, Takeshi Into, Charles J. Lowenstein, Kenji Matsushita

Date : 01/01/2008 Item size : 286326 bytes

Of interest, the development of novel isoform-selective PI3K inhibitor drugs offers a unique opportunity to selectively and differentially target PI3K-driven pathways in the vascular system and may ...

Cardiovascular Research, Review, Fulvio Morello, Alessia Perino, Emilio Hirsch

Date : 01/05/2009 Item size : 517390 bytes

Time for primary review 30 days It is generally accepted that the vascular endothelium is not a simple barrier between the blood stream and vascular bed. Fortunately, many new experimental ...

Cardiovascular Research, Review, Tomoh Masaki

Date : 01/09/1998 Item size : 167248 bytes