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Oxidized low density lipoprotein induces apoptosis via generation of reactive oxygen species in vascular smooth muscle cells Abstract Objective: Death of vascular smooth muscle cell (VSMC) induced ...

Cardiovascular Research, Original Article, Chien-Cheng Hsieh, Mao-Hsiung Yen, Chia-Hung Yen, Ying-Tung Lau

Date : 01/01/2001 Item size : 374782 bytes

The mRNA, phosphorylation, and protein levels of APJ, Akt, and endothelial nitric oxide synthase (eNOS) were analyzed by reverse transcriptionpolymerase chain reaction and Western blotting, ...

Cardiovascular Research, Original Article, Jiu-Chang Zhong, Xi-Yong Yu, Yu Huang, Lai-Ming Yung, Chi-Wai Lau, Shu-Guang Lin

Date : 01/06/2007 Item size : 236658 bytes

Abstract Objective: The aim was to determine whether myofilament Ca2+ sensitivity is altered in skinned cardiac fibres from endotoxin-treated rabbits. Methods: Endotoxin was injected i.v. in ...

Cardiovascular Research, Original Article, Benoı̂t Tavernier, Delphine Garrigue, Claire Boulle, Benoı̂t Vallet, Pascal Adnet

Date : 01/05/1998

Abstract Objective: The primary aim of this study was to investigate whether activation of Na influx via voltage-gated Na channels can elevate sub-sarcolemmal (fuzzy-space [Na] and transiently ...

Cardiovascular Research, Original Article, Benjamin d.Z Silverman, Alice Warley, Jonathan I.A Miller, Andrew F James, Michael J Shattock

Date : 15/03/2003

The increased Zn2+ was prevented by 5-hydroxydecanoate (5HD) but was mimicked by diazoxide, implying that mitochondrial KATP channel opening may account for this effect. Since chelation of Zn2+ ...

Cardiovascular Research, Original Article, Youngho Jang, Huihua Wang, Jinkun Xi, Robert A. Mueller, Edward A. Norfleet, Zhelong Xu

Date : 15/07/2007

Abstract Objective Our aim was to investigate the regulation of glucose and fatty acid metabolism in cardiomyocytes by the globular (gAd) and full-length (fAd) forms of ...

Cardiovascular Research, Original Article, Rengasamy Palanivel, Xiangping Fang, Min Park, Megumi Eguchi, Shelley Pallan, Sabrina De Girolamo, Ying Liu, Yu Wang, Aimin Xu, Gary Sweeney

Date : 01/07/2007

Conclusions: Neonatal and adult cardiomyocytes are resistant to the expression of pro-inflammatory genes due to impairment in the activation of IκB kinase, a process that might contribute to ...

Cardiovascular Research, Research Article, Nora Goren, Jimena Cuenca, Paloma Martín-Sanz, Lisardo Boscá

Date : 01/11/2004

Results: Histopathological examination revealed extensive myocardial destruction and massive infiltration of inflammatory cells in the vesnarinone-untreated ...

Cardiovascular Research, Original Article, Shigeru Ishiyama, Michiaki Hiroe, Toshio Nishikawa, Takashi Shimojo, Tetsumi Hosokawa, Ikuo Ikeda, Tetsuya Toyozaki, Takeshi Kasajima, Fumiaki Marumo

Date : 01/08/1999

To investigate potential mechanisms for this observation, we investigated the role of MMP-9 in smooth muscle cell (SMC)-mediated collagen gel contraction, an in vitro model of constrictive ...

Cardiovascular Research, Original Article, Olivier D. Defawe, Richard D. Kenagy, Chun Choi, Samuel Y.C. Wan, Christophe Deroanne, Betty Nusgens, Natzi Sakalihasan, Alain Colige, Alexander W. Clowes

Date : 01/05/2005

Abstract Objectives: ATP-sensitive potassium channels (K+ATP) prominently contribute to basal coronary tone; however, flow reserve during exercise remains unchanged despite channel blockade with ...

Cardiovascular Research, Original Article, Pasquale Pagliaro, Nazareno Paolocci, Takayoshi Isoda, Walter F Saavedra, Genshiro Sunagawa, David A Kass

Date : 01/03/2000