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Methods and results LA-remodelling was studied in dogs with heart failure (HF) induced by ventricular tachypacing (VTP, 240 bpm), and in mice with left-ventricular (LV) dysfunction due to myocardial ...

Cardiovascular Research, Chen, Yu, Surinkaew, Sirirat, Naud, Patrice, Qi, Xiao-Yan, Gillis, Marc-Antoine, Shi, Yan-Fen, Tardif, Jean-Claude, Dobrev, Dobromir, Nattel, Stanley

Date : 01/03/2017 Item size : 142189 bytes

In atrial fibrillation (AF), the high atrial rate abbreviates the atrial action potential duration primarily by reduced ICa,L and increased inward-rectifier K+ currents like the background current ...

Cardiovascular Research, Dobrev, Dobromir, Wettwer, Erich

Date : 01/06/2008 Item size : 125314 bytes

Abstract Aims Although atrial tachycardia (AT) remodelling promotes agonist-independent, constitutively active, acetylcholine-regulated K+-current (IK,ACh) that increases susceptibility to atrial ...

Cardiovascular Research, Voigt, Niels, Maguy, Ange, Yeh, Yung-Hsin, Qi, Xiaoyan, Ravens, Ursula, Dobrev, Dobromir, Nattel, Stanley

Date : 01/01/2008 Item size : 251668 bytes

Differential phosphorylation-dependent regulation of constitutively active and muscarinic receptor-activated IK,ACh channels in patients with chronic atrial fibrillation Methods: We used ...

Cardiovascular Research, Voigt, Niels, Friedrich, Adina, Bock, Manja, Wettwer, Erich, Christ, Torsten, Knaut, Michael, Strasser, Ruth H., Ravens, Ursula, Dobrev, Dobromir

Date : 01/06/2007 Item size : 315847 bytes

[...]the therapeutic potential of I-1 in heart failure and arrhythmias has recently been addressed by the generation and analysis of several I-1 genetic mouse models. Introduction The prevalence of ...

Cardiovascular Research, Wittköpper, Katrin, Dobrev, Dobromir, Eschenhagen, Thomas, El-Armouche, Ali

Date : 01/08/2011 Item size : 429005 bytes

Atrial fibrillation (AF), the most common sustained arrhythmia, is associated with substantial cardiovascular morbidity and mortality, with stroke being the most critical complication.1 Present drugs ...

Cardiovascular Research, Dobrev, Dobromir, Nattel, Stanley

Date : 01/03/2011 Item size : 158514 bytes

[...]Sp mice exhibited increased atrial ectopy and susceptibility to pacing-induced AF, both of which were also prevented by the RyR2 S2814A mutation. Previously, studies have found that protein ...

Cardiovascular Research, Chiang, David Y., Li, Na, Wang, Qiongling, Alsina, Katherina M., Quick, Ann P., Reynolds, Julia O., Wang, Guoliang, Skapura, Darlene, Voigt, Niels, Dobrev, Dobromir, Wehrens, ...

Date : 01/07/2014

The loss of a K+ current can impair repolarization, but there is a redundancy of K+ currents so that when one K+ current is dysfunctional, other K+ currents increase to compensate, a phenomenon ...

Cardiovascular Research, Michael, Georghia, Xiao, Ling, Qi, Xiao-Yan, Dobrev, Dobromir, Nattel, Stanley

Date : 15/02/2009 Item size : 521202 bytes

The potential relevance of increased incidence of spontaneous SR Ca2+ release for both AF induction and/or maintenance and the development of novel mechanism-based therapeutic approaches will be ...

Cardiovascular Research, Dobrev, Dobromir, Voigt, Niels, Wehrens, Xander H.T.

Date : 01/03/2011 Item size : 490642 bytes

Chronic cardiac disease is associated with structural, mechanical, and electrical remodeling processes that comprise activation of numerous signal transduction pathways [1]. In hypertrophy and heart ...

Cardiovascular Research, Dobrev, Dobromir

Date : 01/11/2003 Item size : 139536 bytes